{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:54:28Z","timestamp":1793987668024,"version":"4.8.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Atrial fibrillation (AF) is the most common sustained arrhythmia, with radiofrequency ablation (RFA) being a key treatment strategy. Despite its success, AF recurrence postablation is significant, and the ablation index (AI) was introduced to improve lesion quality and clinical outcomes. The aim of this study was to provide updated safety and efficacy data regarding AI\u2010guided ablation strategy. A systematic literature review was performed utilizing the PubMed, Embase, Cochrane, and Web\u2010of\u2010Science databases to retrieve double\u2010arm retrospective and prospective studies comparing AI\u2010guided ablation to non\u2010AI guided ablation from inception until January\u20102024. The initial literature search yielded 700 studies, with 18 double\u2010arm full articles included in the analysis after screening and exclusions. The cohort consisted of 2030 patients undergoing AI\u2010guided ablation and 1580 undergoing non\u2010AI\u2010guided ablation. The average age of the cohort was 64.09\u2009\u00b1\u20099.86 years, with a median follow\u2010up period of 12 months. AI\u2010guided ablation was associated with lower AF recurrence (22% vs 32%, OR\u2009=\u20090.67, 95% CI\u2009=\u20090.59\u20130.77,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). It also resulted in shorter total procedure time (145\u2009min vs 159\u2009min, SMD\u2009=\u2009\u20100.47, 95% CI\u2009=\u2009\u22120.78\u2013\u20100.16,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005) and fluoroscopy time (8.8\u2009min vs 11.3\u2009min, SMD\u2009=\u2009\u22120.35, 95% CI\u2009=\u2009\u20100.55 to \u20100.20,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). No significant difference was observed in ablation time. First pass isolation was more likely with AI\u2010guided ablation (80% vs 60%, OR\u2009=\u20091.44, 95% CI\u2009=\u20091.04\u20132.01,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.037). Complication rates were similar between groups (OR\u2009=\u20090.79, 95% CI\u2009=\u20090.47\u20131.32,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.33). In conclusion, AI\u2010guided ablation significantly reduces AF recurrence and procedure times compared to non\u2010AI\u2010guided methods, without increasing complication rates, indicating its efficacy and safety in clinical practice.\n                  <\/jats:p>","DOI":"10.1111\/jce.70039","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T07:37:39Z","timestamp":1754897859000},"page":"2597-2607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ablation Index\u2010Guided Radiofrequency Ablation for Atrial Fibrillation: An Updated Meta\u2010Analysis on Its Procedural Efficacy and Safety Profiles"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-1496","authenticated-orcid":false,"given":"Majd Al Deen","family":"Alhuarrat","sequence":"first","affiliation":[{"name":"Division of Cardiology University of Massachusetts Medical School Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Flomenbaum","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Montefiore Medical Center Albert Einstein College Medicine Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0720-3380","authenticated-orcid":false,"given":"Marco","family":"Schiavone","sequence":"additional","affiliation":[{"name":"Department of Clinical Electrophysiology and Cardiac Pacing Centro Cardiologico Monzino IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8637-4233","authenticated-orcid":false,"given":"Maisha","family":"Maliha","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Jacobi Medical Center Albert Einstein College Medicine Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad Anas","family":"Oudih","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Montefiore Medical Center Albert Einstein College Medicine Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munther","family":"Hammad","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Medstar Washington Center Georgetown University School of Medicine Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Freilich","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Montefiore Medical Center Albert Einstein College Medicine Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiadong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Montefiore Medical Center Albert Einstein College of Medicine Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo Mirco","family":"La Fazia","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute Austin TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aung","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Montefiore Medical Center Albert Einstein College of Medicine Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Marazzato","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Montefiore Medical Center Albert Einstein College of Medicine Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel J.","family":"Apple","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Montefiore Medical Center Albert Einstein College of Medicine Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ammirati","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Montefiore Medical Center Albert Einstein College of Medicine Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stepan","family":"Esagian","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Jacobi Medical Center Albert Einstein College Medicine Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batool","family":"Al Zyoud","sequence":"additional","affiliation":[{"name":"Division of Pharmacy Jordan University of Science &amp; Technology Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengwei","family":"Zou","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Montefiore Medical Center Albert Einstein College of Medicine Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelia","family":"Minuti","sequence":"additional","affiliation":[{"name":"Head, Research &amp; Education, D. 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