{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:09:46Z","timestamp":1777734586461,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Primary analysis of the HINODE study revealed that mortality and ventricular tachyarrhythmia event rates for patients with primary prevention of sudden cardiac death in Japan were comparable to those of Western patients. Sub\u2010analysis aimed to evaluate event rates in relation to accumulated risk factors (RFs) (left ventricular ejection fraction \u2264\u200935%, New York Heart Association class III\/IV, left bundle branch block\/wide QRS, renal dysfunction, diabetes, atrial fibrillation, myocardial infarction, age &gt;\u200970 years, and smoking).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      Implantable cardioverter defibrillator (ICD) (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009102) and cardiac resynchronization therapy\u2013defibrillator (CRT\u2010D) (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200969) enrollees were evaluated for first appropriately treated ventricular tachycardia or fibrillation (VT\/VF), recurrent heart failure (HF) hospitalizations, and all\u2010cause mortality. Event rates were compared for patients with lower\u2010risk (2\u20133 RFs) and higher\u2010risk (4\u20135 RFs) using time to event analyses. The ICD\u2010cohort contained 50 (49%) lower\u2010risk and 52 (51%) higher\u2010risk patients, and the CRT\u2010D\u2010cohort 21 (30%) lower\u2010risk and 48 (70%) higher\u2010risk patients. Over 24 months, no significant difference was observed in the VT\/VF event rate among the higher\u2010risk group compared to the lower\u2010risk group for either device cohort (ICD: 17% vs. 10%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.61; CRT\u2010D: 6% vs. 5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.79). Similarly, no significant difference was observed in the rate of all\u2010cause mortality, although higher\u2010risk patients trended towards more mortality (ICD: 15% vs. 7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.15; CRT\u2010D: 13% vs. 5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.33) For the ICD cohort, the risk of HF hospitalization was 2.24 (95% CI: 1.24\u20134.03) times greater in the higher\u2010risk group compared to the lower\u2010risk group and among those hospitalized for HF, the length of stay was significantly longer for the higher\u2010risk group (median 27 days per year vs. 10 days per year,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013). No significant difference in the rate of HF hospitalizations was detected for the CRT\u2010D cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The implantation of ICD should be considered despite the number of RFs to prevent sudden cardiac death. Proper CRT\u2010D implantation may reduce the number of RFs over time and shorten the duration of HF\u2010hospitalization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70046","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T07:50:37Z","timestamp":1755503437000},"page":"2830-2838","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Risk Factors and Cardiac Outcomes in Patients With Primary Prevention of Sudden Cardiac Death: HINODE Study Sub Analysis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8202-9867","authenticated-orcid":false,"given":"Hiroshi","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Nippon Medical School Bunkyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Nippon Medical School Bunkyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Nippon Medical School Bunkyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kokura Memorial Hospital Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Kusano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine National Cerebral and Cardiovascular Center Osaka 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University Faculty of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Mitsuhashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hoshi General Hospital Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyoaki","family":"Murohara","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3183-5660","authenticated-orcid":false,"given":"Nobuhiro","family":"Nishii","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Therapeutics Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama 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