{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:01:54Z","timestamp":1780351314843,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical outcomes after atrial fibrillation (AF) ablation using the novel dual\u2010sized cryoballoon (DS\u2010CB) are limited. This study aimed to analyze real\u2010world data on the DS\u2010CB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter observational study included consecutive AF patients who underwent pulmonary vein (PV) isolation (PVI) using a DS\u2010CB catheter (28\u2010mm\/31\u2010mm).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 407 patients (68\u2009\u00b1\u200911 years, 279 men, 251 paroxysmal AF[PAF]), 1528 (95.9%) out of 1594 targeted PVs were successfully isolated with DS\u2010CBs. The total application number and application time were 5 [4\u20106] and 812\u2009\u00b1\u2009207\u2009s, respectively. Cryoballoon\u2010related phrenic nerve injury (PNI) occurred in 23 (5.6%) patients, with 4.7% in the right superior PV (RSPV) and 1.0% in the right inferior PV. All but one patient recovered within 12 months. Additional ablation beyond CB\u2010PVI was performed in 251 (62%) patients. The 1\u2010year arrhythmia freedom was 91.7% (93.3% for PAF and 89.5% for non\u2010PAF,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08), with antiarrhythmic drug use in 23 (9.2%) and 32 (20.6%) PAF and non\u2010PAF patients, respectively. Forty\u2010three patients experienced early recurrence of AF (ERAF) within 2 months of follow\u2010up. In a multivariate Cox regression analysis, including baseline and procedural parameters, a higher nadir balloon temperature in the RSPV (hazard ratio[HR]\u2009=\u20091.076, 95% confidence interval[CI]\u2009=\u20091.024\u20131.130,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and all 4 PVI with 31\u2010mm balloons (HR\u2009=\u20093.085, 95% CI\u2009=\u20091.701\u20135.595,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) were significantly associated with arrhythmia recurrence. In the multivariate analysis including all parameters, ERAF (HR\u2009=\u20095.066, 95% CI\u2009=\u20092.928\u20138.767,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) was the strongest predictor of arrhythmia recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The 1\u2010year arrhythmia freedom post\u2010DS\u2010CB ablation was 91.7% in real\u2010world clinical practice; however, right PNI remained a common complication, even with the balloon size adjustability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70066","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T11:24:47Z","timestamp":1755516287000},"page":"2878-2884","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["One\u2010Year Clinical Outcomes of Novel Dual\u2010Sized Cryoballoon Ablation for Atrial Fibrillation"],"prefix":"10.1111","volume":"36","author":[{"given":"Yosuke","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Cardiology Sakakibara Heart Institute Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0230-0934","authenticated-orcid":false,"given":"Shinsuke","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Institute of Science Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Nitta","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sakakibara Heart Institute Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5085-0810","authenticated-orcid":false,"given":"Takeshi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology NHO Disaster Medical Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4661-2999","authenticated-orcid":false,"given":"Yasuteru","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Yokohama City Bay Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2179-3786","authenticated-orcid":false,"given":"Osamu","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Saitama Hospital Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sakakibara Heart Institute Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6765-0185","authenticated-orcid":false,"given":"Shu","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Cardiology NHO Disaster Medical Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Sagawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Yokohama City Bay Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7027-2613","authenticated-orcid":false,"given":"Yukihiro","family":"Inamura","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Saitama Hospital Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Institute of Science Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Institute of Science Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Sasano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Institute of Science Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.03.017"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.03.021"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602014"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2029554"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.05.047"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2023.101326"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16415"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16220"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.124.013088"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.12.034"}],"container-title":["Journal 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