{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:10:05Z","timestamp":1787015405758,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ventricular tachycardia (VT) is a major contributor to sudden cardiac death among patients with ischemic heart disease (IHD). While catheter ablation reduces the arrhythmic burden, the impact on long\u2010term outcomes remains uncertain. We assess the efficacy of catheter ablation in patients with IHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a meta\u2010analysis by systematically searching electronic databases from inception to April 2025. Pairwise, reconstructed time\u2010to\u2010event data meta\u2010analyses and Trial Sequential analyses were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of seven studies (1192 participants) were included. Among patients with IHD with ICD, VT ablation was associated with a significant reduction in ICD shocks (RR\u2009=\u20090.50, 95% CI\u2009=\u2009[0.34\u20130.74]), a trend toward reduced VT storm (RR\u2009=\u20090.64, 95% CI\u2009=\u2009[0.40\u20131.04],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.07), and lower rates of cardiovascular hospitalization (RR\u2009=\u20090.73, 95% CI\u2009=\u2009[0.53\u20131.01],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06) compared to ICD alone. However, no significant differences were observed when compared to patients receiving ICD plus antiarrhythmic drugs (AADs). VT ablation showed no significant impact on mortality or VT\/VF recurrence compared to either ICD alone or ICD with AADs. Reconstructed Kaplan\u2013Meier analysis for all\u2010cause mortality showed no significant difference between VT ablation and AAD\u202f\u2009+\u2009\u202fICD. Trial Sequential Analysis provided conclusive evidence for VT\/VF recurrence, while further data is required for other outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among patients with IHD with ICD, VT ablation reduces ICD shocks, VT storm, and cardiovascular hospitalizations compared to ICD\u2010only therapy, but offers no significant advantage over ICD combined with AADs. VT ablation does not impact overall mortality or the recurrence of VT\/VF. Trial sequential analysis confirmed conclusive evidence for VT\/VF recurrence, while additional data is needed for other outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70075","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T03:46:01Z","timestamp":1758080761000},"page":"2934-2949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Catheter Ablation for Ventricular Tachycardia in Ischemic Cardiomyopathy: A Meta\u2010Analysis With Reconstructed Time\u2010to\u2010Event and Trial Sequential Analysis"],"prefix":"10.1111","volume":"36","author":[{"given":"Hossam","family":"Elbenawi","sequence":"first","affiliation":[{"name":"Cardiovascular Medicine Department Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7265-6737","authenticated-orcid":false,"given":"Youmna","family":"Ayman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Port Said University Port Fuad Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1767-5966","authenticated-orcid":false,"given":"Ahmed","family":"Hashim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Department Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Wagdy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Modern University for Technology and Information Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belal Mohamed","family":"Hamed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Al\u2010Azhar Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyesh","family":"Thakurathi","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Hartford Hospital Hartford Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4298-5456","authenticated-orcid":false,"given":"Ali Saad","family":"Al\u2010Shammari","sequence":"additional","affiliation":[{"name":"College of Medicine University of Baghdad Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kareem A.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Hartford Hospital Hartford Connecticut 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