{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:43:01Z","timestamp":1773423781060,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We evaluated the impact of pulsed\u2010field (PFA) vs. radiofrequency ablation (RFA) on long\u2010term ablation outcome in AF patients and whether the benefit was extended to all age groups, in a real\u2010world population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive AF patients undergoing their first ablation procedure were classified based on their age at baseline; group 1: &gt;\u200960 years and group 2: \u2264\u200960 years. Each group were then subclassified based on the energy modality used; group 1A or 2A: received RFA, and group 1B or 2B: underwent PFA. All patients received isolation of PVs and left atrial posterior wall.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1386 patients were included in group 1 (Gr 1A: 954; Gr 1B: 432) and 414 subjects in group 2 (Gr 2A: 284; Gr 2B: 130). Patients in group 1 were sicker with more comorbidities.<\/jats:p>\n                    <jats:p>\n                      At the end of 1\u2010year follow\u2010up, significantly higher recurrence rate was reported in group 1 patients receiving RFA compared to PFA (249 (26.1%) vs. 45 (10.4%),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas the recurrence rate was comparable between the two subgroups in group 2 (RFA: 69 (24.3%) vs. PFA: 22 (17%),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.095).\n                    <\/jats:p>\n                    <jats:p>\n                      Mean time to recurrence was significantly longer in the Gr. 2B (PFA) population compared to RFA (7.21\u2009\u00b1\u20091.87 vs. 7.75\u2009\u00b1\u20092.03 months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) and comparable in Gr. 1 (RFA: 7.98\u2009\u00b1\u20091.29 vs. PFA: 8.12\u2009\u00b1\u20091.80 months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.531).\n                    <\/jats:p>\n                    <jats:p>\n                      After controlling for the variables in the multivariate model, PFA was associated with lower risk (OR\u2009=\u20090.378, 95% CI 0.265, 0.539;\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009&lt;\u20090.001) and Persistent AF with higher risk of recurrence (OR\u2009=\u20091.745, 95% CI 1.562, 1.986;\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.040).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PFA was associated with a significantly lower recurrence rate in patients &gt;\u200960 years of age with more comorbidities compared to RFA. However, in patients aged \u2264\u200960 years, no difference in RFA vs. PFA in terms of recurrence rate was observed. Mean time to recurrence was comparable between PFA and RFA subgroups in the group 1 population, whereas it was significantly higher in group 2 PFA vs. RFA subgroup.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70101","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T07:54:46Z","timestamp":1758786886000},"page":"3156-3162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010Term Outcome of Radiofrequency Versus Pulsed\u2010Field Ablation in Atrial Fibrillation Patients Aged More Than 60 Years Undergoing Their First Catheter Ablation"],"prefix":"10.1111","volume":"36","author":[{"given":"Pamela Horton","family":"Embrey","sequence":"first","affiliation":[{"name":"Division of Internal Medicine The University of Texas Health Science Center at Houston Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6601-944X","authenticated-orcid":false,"given":"Sanghamitra","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute St. David's Medical Center Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prem Geeta","family":"Torlapati","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute St. David's Medical Center Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo Mirco","family":"La Fazia","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute St. David's Medical Center Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carola","family":"Gianni","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute St. David's Medical Center Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaseen","family":"Eleyan","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute St. David's Medical Center Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute St. David's Medical Center Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Mayedo","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute St. David's Medical Center Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8547-025X","authenticated-orcid":false,"given":"Amin","family":"Al\u2010Ahmad","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute St. David's Medical Center Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John David","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute St. David's Medical Center Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Allison","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute St. David's Medical Center Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weeranun","family":"Bode","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute St. David's Medical Center Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. J.","family":"Gallinghouse","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute St. David's Medical Center Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney","family":"Horton","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute St. David's Medical Center Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5487-0728","authenticated-orcid":false,"given":"Andrea","family":"Natale","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute St. David's Medical Center Austin Texas USA"},{"name":"Metro Health Medical Center Case Western Reserve University School of Medicine Cleveland Ohio USA"},{"name":"Department of Biomedicine and Prevention, Division of Cardiology University of Tor Vergata Rome Italy"},{"name":"Interventional Electrophysiology Scripps Clinic San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61774-8"},{"key":"e_1_2_10_3_1","first-page":"19","article-title":"Atrial Fibrillation","volume":"4","author":"Aronow W. 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