{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:43:52Z","timestamp":1790959432102,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Left bundle branch area pacing (LBBAP) is an emerging strategy for cardiac resynchronization therapy (CRT), but its implementation in heart failure patients remains challenging. This study aimed to assess whether the initial V\n                      <jats:sub>6<\/jats:sub>\n                      R\u2010wave peak time (V\n                      <jats:sub>6<\/jats:sub>\n                      RWPT) during right ventricular septal pacing (RVSP) for lead localization can predict successful LBBAP implantation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      Consecutive patients with left bundle branch block (LBBB) and left ventricular ejection fraction (LVEF)\u2009&lt;\u200950% who met CRT indications were included. Clinical, echocardiographic, and electrocardiographic variables were collected. Among 99 patients enrolled in the study, the success rates for LBBAP and LBBP were 73.7% and 63.6%, respectively. Multivariate regression analysis revealed that baseline Strauss LBBB (OR:5.04, 95% CI:1.45\u201317.54,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) and shorter RVSP V\n                      <jats:sub>6<\/jats:sub>\n                      RWPT (per 10\u2009ms, OR:0.42, 95% CI:0.29\u20130.59,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) had a greater likelihood of successful LBBAP. RVSP V\n                      <jats:sub>6<\/jats:sub>\n                      RWPT (cutoff: 145\u2009ms) yielded the highest area under the curve (AUC:0.888), significantly outperforming LVEDD (AUC:0.721), LAD (AUC:0.709), baseline Strauss LBBB (AUC:0.694), and baseline QRSd (AUC:0.629) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Among 56 patients who underwent cardiac magnetic resonance imaging, RVSP V\n                      <jats:sub>6<\/jats:sub>\n                      RWPT correlated significantly with both global (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.592,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and septal scar percentages (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.598,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      V\n                      <jats:sub>6<\/jats:sub>\n                      RWPT during RVSP is a novel predictor of successful LBBAP implantation in heart failure patients with LBBB. This marker demonstrates strong predictive value and correlates with cardiac scar burden. The RVSP V\n                      <jats:sub>6<\/jats:sub>\n                      RWPT assessment dynamically guides CRT strategy optimization during implantation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70110","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:51:33Z","timestamp":1758279093000},"page":"3136-3145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Right Ventricular Septal Pacing\u2010Derived V\n                    <sub>6<\/sub>\n                    R\u2010Wave Peak Time Predicts Successful Left Bundle Branch Area Pacing in Patients With Heart Failure and Left Bundle Branch Block"],"prefix":"10.1111","volume":"36","author":[{"given":"Mengxing","family":"Cai","sequence":"first","affiliation":[{"name":"Arrhythmia Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing Xicheng District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongli","family":"Chen","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing Xicheng District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing Xicheng District 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Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Xicheng District, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing Xicheng District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandu","family":"Yang","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing Xicheng District 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Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing Xicheng District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Dai","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing Xicheng District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing Xicheng District 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