{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:14:47Z","timestamp":1772986487657,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Brugada syndrome (BrS) significantly contributes to sudden cardiac death in otherwise healthy individuals, primarily due to life\u2010threatening ventricular fibrillation (VF). Traditional treatment prevents SCD but does not eliminate the risk of recurrent VF episodes. Recent developments in catheter ablation techniques targeting the arrhythmogenic substrate in the right ventricular epicardium have emerged as promising alternatives; however, there is a lack of randomized controlled trials (RCTs). To address this, we conducted a reconstructed individual patient data (IPD) meta\u2010analysis to synthesize RCT evidence and estimate the time to benefit (TTB) of epicardial ablation in malignant BrS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched major databases for RCTs comparing epicardial ablation versus ICD only in patients with malignant forms of BrS. IPD were reconstructed from Kaplan\u2013Meier curves. Hazard ratios (HRs) and 95% confidence intervals (CI) were estimated using Cox regression, and Weibull models were applied to calculate TTB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two RCTs (Nademandee et al; and Pappone et al.) including 90 patients (mean age 43.5 years) were included. Epicardial ablation therapy reduced the risk of VF recurrence (HR 0.17; 95% CI: 0.07\u20130.43;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The TTB to prevent one VF per 100 patients was 0.2 months (97.5% CI: 0.1\u20138.1 months).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with malignant forms of BrS, epicardial ablation was linked to a reduction in VF. These findings indicate that, for selected patients, adjunctive ablation procedures may provide a more favorable benefit profile than relying solely on ICDs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70188","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T06:40:57Z","timestamp":1763361657000},"page":"81-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time to Benefit of Epicardial Ablation in Malignant Forms of Brugada Syndrome: A Reconstructed Individual Patient Data Meta\u2010Analysis"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3408-2115","authenticated-orcid":false,"given":"Lucas M.","family":"Barbosa","sequence":"first","affiliation":[{"name":"Department of Medicine Federal University of Minas Gerais Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius Martins Rodrigues","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Goi\u00e1s Goi\u00e2nia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo N.","family":"Consoli","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3457-1605","authenticated-orcid":false,"given":"Cristiano","family":"Pisani","sequence":"additional","affiliation":[{"name":"Instituto Do Cora\u00e7\u00e3o (InCor) University of S\u00e3o Paulo, Arrhythmia Unit S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Darrieux","sequence":"additional","affiliation":[{"name":"Instituto Do Cora\u00e7\u00e3o (InCor) University of S\u00e3o Paulo, Arrhythmia Unit S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Brugada","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Clinic Cardiovascular Institute, University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maur\u00edcio Ibrahim","family":"Scanavacca","sequence":"additional","affiliation":[{"name":"Instituto Do Cora\u00e7\u00e3o (InCor) University of S\u00e3o Paulo, Arrhythmia Unit S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac262"},{"key":"e_1_2_10_3_1","article-title":"Spotlight on the 2022 ESC Guideline Management of Ventricular Arrhythmias and Prevention of Sudden Cardiac Death: 10 Novel key Aspects","volume":"25","author":"K\u00f6nemann 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