{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:01:35Z","timestamp":1783033295756,"version":"3.54.6"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cardiac resynchronization therapy (CRT) improves clinical outcomes in patients with heart failure with reduced ejection fraction (HFrEF). However, data on its efficacy in patients with sarcoidosis and HFrEF are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the TriNetX network, we identified patients with sarcoidosis, heart failure with a left ventricular ejection fraction (LVEF) below 35%, and either left bundle branch block (LBBB) or prolonged QRS duration (\u2009&gt;\u2009150\u2009ms) between 2014 and 2019. Patients were categorized into two cohorts: (1) those who received CRT and (2) those who received an ICD\u2010only implant. Five\u2010year outcomes included all\u2010cause mortality, all\u2010cause hospitalization, heart failure exacerbation, and the proportion of patients with improvement in LVEF to greater than 40% and greater than 50%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 245 eligible patients, we identified a cohort of 87 patients (mean age 62.6\u2009\u00b1\u20099.5 years) who received CRT and 87 patients (mean age 62.1\u2009\u00b1\u200911.1 years) who received ICD\u2010only implant, with similar propensity scores, and included them in a comparative analysis. At 5\u2010year follow\u2010up, the CRT group demonstrated outcomes comparable to the ICD\u2010only implant group for all\u2010cause mortality (14.9% vs. 20.7%; HR 0.63; 95% CI 0.31\u20131.28;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.19), all\u2010cause hospitalization (83.9% vs. 77.0%; HR 1.24; 95% CI 0.89\u20131.73;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.19), and heart failure exacerbation (28.7% vs. 28.7%; HR 0.90; 95% CI 0.52\u20131.57;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.72). The proportion of patients with improvement in LVEF to greater than 40% and greater than 50% was also similar in both groups (LVEF\u2009&gt;\u200940%, 43.7% vs. 33.3%; HR 1.30; 95% CI 0.80\u20132.10;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.29; LVEF\u2009&gt;\u200950%, 31.0% vs. 17.2%; HR 1.72; 95% CI 0.92\u20133.24;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.09).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CRT implantation had similar long\u2010term outcomes compared to ICD\u2010only implantation in patients with sarcoidosis and HFrEF, particularly all\u2010cause mortality, all\u2010cause hospitalization, heart failure exacerbation, and the proportion of patients with improvement in LVEF to greater than 40% and greater than 50%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70204","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T04:35:32Z","timestamp":1764045332000},"page":"119-125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Propensity\u2010Matched Five\u2010Year Cardiac Resynchronization Therapy Outcomes in Sarcoidosis With Heart Failure"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5559-7236","authenticated-orcid":false,"given":"Yong Hao","family":"Yeo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine\/Pediatrics Corewell Health William Beaumont University Hospital Royal Oak Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4200-3983","authenticated-orcid":false,"given":"Tze Ern","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Medicine One Brooklyn Health System\/Interfaith Medical Center Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravinthan","family":"Vignarajah","sequence":"additional","affiliation":[{"name":"Department of Medicine Cleveland Clinic Fairview Hospital Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7682-8934","authenticated-orcid":false,"given":"Min Choon","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix Arizona USA"},{"name":"Department of Medicine New York Medical College at St. Michael Medical Center Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishanthi","family":"Vigneswaramoorthy","sequence":"additional","affiliation":[{"name":"Department of Medicine SUNY Upstate Medical University Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2470-2862","authenticated-orcid":false,"given":"Hicham","family":"El\u2010Masry","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Sorajja","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9560-1102","authenticated-orcid":false,"given":"Abhishek","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester 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