{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:34:39Z","timestamp":1786714479107,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Insertable cardiac monitors (ICMs) provide long\u2010term continuous monitoring for arrhythmia diagnosis and management for various clinical indications. However, little data exists on comprehensive real\u2010world arrhythmia diagnostic yield and therapy rates in patients indicated for ICMs with validated artificial intelligence (AI) algorithms enabling large\u2010scale, automated adjudication of ICM\u2010detected episodes. We report the largest real\u2010world analysis of arrhythmia detection as well as medical and procedural therapies in patients with ICMs implanted for guideline\u2010approved indications with long\u2010term monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients who received a Reveal LINQ ICM between October 1, 2016, and June 30, 2020, with \u2265\u20091 year of follow\u2010up were identified in two databases (Medtronic CareLink data warehouse,\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200912 020, and Optum Clinformatics Data Mart claims database,\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200917 037) to analyze arrhythmia detections and therapeutic interventions, respectively. Patients were categorized by clinical indication for ICM placement. All device\u2010detected ECGs were identified and processed through arrhythmia\u2010specific AI algorithms. Therapeutic interventions included procedural interventions (cardiovascular implantable electronic device implantation, cardioversions, and ablations) and medication initiation or titration (antiarrhythmics, rate\u2010control medications, and oral anticoagulants) after ICM implant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean (SD) follow\u2010up in the CareLink and Clinformatics claims databases was 24.6 (12.7) and 40.8 (15.6) months, respectively. Of the 12 020 patients in the arrhythmia detection analysis, 7284 (60.6%) had \u2265\u20091 arrhythmia detected (56.3% in the suspected AF population; 80.1% in the AF management population), and 3,476 (28.9%) had \u2265\u20092 arrhythmias detected during long\u2010term follow\u2010up. Among syncope patients with arrhythmia(s) detected, 71.2% had a finding other than pause\/bradycardia; 75.1% of cryptogenic stroke patients and 62.6% of AF management patients with arrhythmias had \u2265\u20091 finding other than AF. Of the 17 037 patients in the therapeutic interventions analysis, 9820 (57.6%) had a therapeutic action post\u2010ICM insertion, with 25% of all patients receiving a procedural intervention, and &gt;\u200950% undergoing a medication adjustment. Mean (SD) follow\u2010up to first arrhythmia detection was 7 (9) months. Mean (SD) duration from ICM insertion to therapeutic action was 13 (13) months for procedures and 7 (11) months for medication initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Long\u2010term continuous monitoring with ICMs enables identification of multiple arrhythmias that may have otherwise remained undetected and rules out arrhythmias in ~40% regardless of indication. Medication adjustments and\/or procedural interventions related to the management of arrhythmias were observed in over half of ICM recipients during long\u2010term follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70214","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T04:30:43Z","timestamp":1766032243000},"page":"359-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Large, Real\u2010World Cohort Analysis of Arrhythmia Detection and Therapeutic Interventions in Patients With Insertable Cardiac Monitors and Long\u2010Term Monitoring"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6972-3448","authenticated-orcid":false,"given":"Sandeep A.","family":"Saha","sequence":"first","affiliation":[{"name":"Oregon Heart Center Salem Oregon 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