{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:34:31Z","timestamp":1786714471926,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cryoballoon ablation (CB) is a well\u2010established thermal technique for pulmonary vein isolation (PVI), while balloon\u2010in\u2010basket pulsed field ablation (BiB\u2010PFA) represents a novel non\u2010thermal alternative. Both single\u2010shot systems may trigger systemic inflammation and myocardial injury, yet direct comparisons are lacking. This study aimed to compare inflammatory and myocardial biomarker responses following first\u2010time PVI using CB or BiB\u2010PFA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective, single\u2010center study, 100 patients undergoing PVI for symptomatic paroxysmal or persistent atrial fibrillation (AF) were enrolled (CB:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009\u202f50; BiB\u2010PFA:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009\u202f50). Venous blood samples were collected before and on the morning after ablation to assess leukocytes, C\u2010reactive protein (CRP), platelets, troponin T, creatine kinase (CK), myoglobin, creatinine, and estimated glomerular filtration rate. Baseline characteristics, procedural data, and acute success were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients in the CB group were older (74 vs. 65 years;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009\u202f0.01) and had higher CHA\u2082DS\u2082\u2010VAcore (3.0 vs. 2.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f\u2009=\u2009\u202f0.009). Acute PVI was achieved in all cases CB was associated with greater increases in leukocytes (\u03942.5 vs. 1.1\u2009\u00d7\u200910\u2079\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f\u2009=\u2009\u202f0.05) and CRP (\u03945.8 vs. 3.4\u2009mg\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009\u202f0.02), whereas BiB\u2010PFA showed higher rises in CK (\u0394217 vs. 103\u2009U\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f\u2009=\u2009\u202f0.01) and troponin T (\u03941129 vs. 614.5\u2009ng\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009\u202f0.01). No significant correlation was found between energy delivery and biomarker changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CB and BiB\u2010PFA elicit distinct systemic responses. CB provoked stronger inflammatory activation, while BiB\u2010PFA caused greater myocardial biomarker release, suggesting energy\u2010 and device\u2010specific effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70221","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T05:00:02Z","timestamp":1765256402000},"page":"296-304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inflammatory and Myocardial Biomarker Response Following Pulmonary Vein Isolation: Cryoballoon Versus Balloon\u2010in\u2010Basket Pulsed Field Ablation"],"prefix":"10.1111","volume":"37","author":[{"given":"Jan\u2010Per","family":"Wenzel","sequence":"first","affiliation":[{"name":"Department of Rhythmology, University Heart Center L\u00fcbeck University Hospital Schleswig\u2010Holstein L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site L\u00fcbeck  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Hatahet","sequence":"additional","affiliation":[{"name":"Department of Rhythmology, University Heart Center L\u00fcbeck University Hospital Schleswig\u2010Holstein L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Eitel","sequence":"additional","affiliation":[{"name":"Department of Rhythmology, University Heart Center L\u00fcbeck University Hospital Schleswig\u2010Holstein L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site L\u00fcbeck  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raed","family":"Abdessadok","sequence":"additional","affiliation":[{"name":"Department of Rhythmology, University Heart Center L\u00fcbeck University Hospital Schleswig\u2010Holstein L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Rhythmology, University Heart Center L\u00fcbeck University Hospital Schleswig\u2010Holstein L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2367-795X","authenticated-orcid":false,"given":"Julius","family":"Nikorowitsch","sequence":"additional","affiliation":[{"name":"Department of Rhythmology, University Heart Center L\u00fcbeck University Hospital Schleswig\u2010Holstein L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site L\u00fcbeck  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"de Waha","sequence":"additional","affiliation":[{"name":"Department of Rhythmology, University Heart Center L\u00fcbeck University Hospital Schleswig\u2010Holstein L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site L\u00fcbeck  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Zeller","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK) Partner Site L\u00fcbeck  Germany"},{"name":"Institute for Cardiogenetics University Hospital Schleswig\u2010Holstein L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl\u2010Heinz","family":"Kuck","sequence":"additional","affiliation":[{"name":"Department of Rhythmology, University Heart Center L\u00fcbeck University Hospital Schleswig\u2010Holstein L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland Richard","family":"Tilz","sequence":"additional","affiliation":[{"name":"Department of Rhythmology, University Heart Center L\u00fcbeck University Hospital Schleswig\u2010Holstein L\u00fcbeck Germany"},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site L\u00fcbeck  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaf072"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2021.06.016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16157"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae176"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2022.05.020"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2023.11.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.10.030"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-20212-9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15813"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316402"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2024.06.009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000001183"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S422002"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-023-02765-x"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.70221","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:56:50Z","timestamp":1786712210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.70221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/jce.70221"],"URL":"https:\/\/doi.org\/10.1111\/jce.70221","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]},"assertion":[{"value":"2025-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}