{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:06:48Z","timestamp":1791666408772,"version":"4.3.4"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A dual\u2010chamber leadless pacemaker (LP) system has been developed, employing distinct atrial leadless pacemaker (ALP) and ventricular leadless pacemaker (VLP) devices that maintain atrioventricular synchrony via wireless implant\u2010to\u2010implant (i2i) communication with each beat. A new i2i communication\u2010free programming option was introduced to extend battery longevity and minimize unnecessary ventricular pacing by providing rate\u2010modulated atrial pacing with backup ventricular pacing when needed (AAI(R)\u2009+\u2009VVI). The clinical safety and longevity improvement have not been evaluated commercially.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients indicated for dual\u2010chamber pacing with new or existing dual\u2010chamber LP implants were enrolled in this prospective, nonblinded, interventional study. Device diagnostics and battery longevity were interrogated before and after 6 months (6 M) of AAI(R)\u2009+\u2009VVI programming, with any programming\u2010related complications or symptoms noted. Total ALP and VLP longevities were compared for DDD(R) at enrollment versus AAI(R)\u2009+\u2009VVI at 6 M.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Dual\u2010chamber LP systems in 139 patients at six centers were evaluated (76\u2009\u00b1\u200911 years; 53% male; PR 210\u2009\u00b1\u200956\u2009ms; 80% sinus node dysfunction, 16% AV block of any degree), including 16% new and 84% existing implants (enrolled 7.9\u2009\u00b1\u20097.5 months postimplant). The 84 patients completing the study (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200955 did not return) demonstrated a complication\u2010free rate of 100.0% and a symptom\u2010free rate of 97.6% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092; fatigue, dizziness, shortness of breath). In the 32 patients enrolled with existing implants already in DDD(R) mode who also completed the 6 M visit, AAI(R)\u2009+\u2009VVI extended the longevities of ALPs by 93% (5.8\u2009\u00b1\u20091.1 to 11.1\u2009\u00b1\u20092.7 years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and VLPs by 61% (10.9\u2009\u00b1\u20092.1 to 16.9\u2009\u00b1\u20091.2 years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clinical use of AAI(R)\u2009+\u2009VVI programming in dual\u2010chamber LPs over 6 M resulted in no complications, minimal symptoms, and significantly extended ALP and VLP battery longevities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70224","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T07:30:22Z","timestamp":1765783822000},"page":"338-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel Pacing Mode Conserves Battery in Dual\u2010Chamber Leadless Pacemakers"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3461-505X","authenticated-orcid":false,"given":"James E.","family":"Ip","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine\/New York Presbyterian Hospital New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Badie","sequence":"additional","affiliation":[{"name":"Abbott Sylmar California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4317-978X","authenticated-orcid":false,"given":"Mayer","family":"Rashtian","sequence":"additional","affiliation":[{"name":"Huntington Hospital Pasadena California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devi G.","family":"Nair","sequence":"additional","affiliation":[{"name":"St. Bernards Healthcare Jonesboro Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Banker","sequence":"additional","affiliation":[{"name":"Hoag Memorial Hospital Newport Beach California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus","family":"Hadadi","sequence":"additional","affiliation":[{"name":"MedStar Heart and Vascular Institute MedStar Washington Hospital Center Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungmoo","family":"Ryu","sequence":"additional","affiliation":[{"name":"Abbott Sylmar California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Ganz","sequence":"additional","affiliation":[{"name":"Abbott Sylmar California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul N.","family":"Doshi","sequence":"additional","affiliation":[{"name":"HonorHealth Cardiac Arrhythmia Group Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.069006"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.10.020"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaf074"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2025.10.021"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.04.091"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.122.010909"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2001.00358.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90018-i"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad065"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.004404"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2006.10.009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2001.00810.x"}],"container-title":["Journal of Cardiovascular 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