{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:53:37Z","timestamp":1787698417107,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate procedural success, safety, and clinical outcomes of left atrial appendage closure (LAAC) in patients with cardiac amyloidosis (CA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>CA is a progressive, infiltrative cardiomyopathy associated with an elevated risk of thromboembolic events, particularly in the setting of atrial fibrillation (AF). These patients are often elderly and at higher risk of bleeding. While LAAC offers an alternative to oral anticoagulation (OAC) for stroke prevention in high\u2010bleeding\u2010risk AF patients, data on its safety and efficacy in CA remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 21 patients with confirmed CA who underwent LAAC between January 2014 and December 2024. Data on demographics, procedural details, post\u2010procedural management, and outcomes were collected. The primary endpoints were procedural success and incidence of post\u2010procedure thromboembolic and bleeding events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most patients had wild\u2010type transthyretin amyloidosis (90.5%) and persistent AF (71.4%). Procedural success was achieved in 95% of patients, with no intra\u2010 or peri\u2010procedural complications. Over a median follow\u2010up of 24 months, there were no cases of device\u2010related thrombosis or major peri\u2010device leaks. Three patients (14.3%) experienced minor peri\u2010device leak. Two patients (9.5%) had major bleeding, which occurred while on post\u2010procedural OAC. Two patients (9.5%) experienced ischemic stroke or TIA, and both patients were given DOAC as a result (Central illustration).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LAAC appears to be a safe and feasible stroke prevention strategy for patients with CA, achieving high procedural success with low complication rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70234","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T06:58:25Z","timestamp":1768373905000},"page":"510-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety and Efficacy of Left Atrial Appendage Occlusion in Cardiac Amyloidosis: A Single\u2010Center Retrospective Study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9605-1539","authenticated-orcid":false,"given":"Ahmed N","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khodor","family":"Chabaklo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7335-6349","authenticated-orcid":false,"given":"Ashraf","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulino","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Jaber","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Saliba","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oussama","family":"Wazni","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Kanj","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000792"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/AITC202303210"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2022.101571"},{"issue":"3","key":"e_1_2_13_5_1","first-page":"147","article-title":"Atrial Fibrillation in Amyloidotic Cardiomyopathy: Prevalence, Incidence, Risk Factors and Prognostic Role","volume":"22","author":"Longhi S.","year":"2015","journal-title":"Amyloid: The Journal of Protein Folding Disorders: The Official Journal Of The International Society of 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