{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:33:23Z","timestamp":1788482003174,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>There is limited data regarding the use of pulsed\u2010field ablation (PFA) for mitral isthmus (MI) ablation in patients with non\u2010paroxysmal atrial fibrillation (AF). Our aim was to assess the acute efficacy of MI ablation using a pentaspline PFA catheter with two different ablation settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with AF undergoing ablation were consecutively enrolled. All patients underwent pulmonary vein isolation and left atrial posterior wall ablation. MI ablation was performed in up to 4 series (9 PFA applications each) in Cohort A, or in up to 3 series (20 PFA applications each) in Cohort B. Each series was followed by a 20\u2010min observation period to verify the durability of the MI block. The primary endpoints were a first\u2010pass MI block and a final MI block after all ablation series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between September 2024 and June 2025, 70 patients were enrolled: 30 in Cohort A and 40 in Cohort B. A first\u2010pass MI block was achieved in 10 (33.3%) patients in Cohort A and 28 (70%) patients in Cohort B (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). A final MI block was present in 27 (90%) and 35 (87.5%) patients in Cohort A and B, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.00). The median reconduction time was 6\u2009min (IQR 2.8\u20139.4) in Cohort A and 5\u2009min (IQR 2.6\u20138.7) in Cohort B. No major complications occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Using series of 20 PFA applications increased the success rate of a first\u2010pass MI block to 70%. An observation period is recommended to verify the durability of MI block in PFA.<\/jats:p>\n                    <jats:p>Clinical Trial Registration: NCT06803238.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70236","type":"journal-article","created":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T07:06:49Z","timestamp":1766905609000},"page":"390-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute Efficacy of Pulsed\u2010Field Ablation of the Mitral Isthmus Using a Pentaspline Catheter and Two Different Ablation Settings"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1274-6722","authenticated-orcid":false,"given":"Josef","family":"Hornof","sequence":"first","affiliation":[{"name":"Department of Cardiology Kr\u00e1lovsk\u00e9 Vinohrady University Hospital Prague Czech 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