{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:05:14Z","timestamp":1784689514798,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Left bundle branch area pacing (LBBAP) has emerged as a promising physiological pacing strategy. However, its feasibility and safety using conventional stylet\u2010driven leads (SDL) such as INGEVITY+ remain under investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the clinical performance, safety, and follow\u2010up outcomes of LBBAP using the INGEVITY+ lead in a real\u2010world electrophysiology setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From 2021 to 2024, 207 consecutive patients underwent LBBAP implant attempts using the INGEVITY+ lead across 19 centers. Of these, 146 had bradycardia indications, and 61 had heart failure indications. A control group of 200 patients received standard right ventricular (RV) pacing with the same lead. Procedural outcomes, electrical parameters, complications, and mid\u2010term lead performance were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LBBAP was successfully achieved in 201 (97%) cases. Procedural and fluoroscopy times were slightly longer for LBBAP than for RV pacing. Acute complications included one helix fracture, one atrioventricular block, and one septal perforation. During a median follow\u2010up of 9 months, no lead fractures were reported; lead dislodgment occurred in three cases. Kaplan\u2013Meier analysis showed no significant difference in time to first lead\u2010related complication between the LBBAP and RV pacing groups (hazard ratio: 4.69, 95%CI: 0.63\u201334.90,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.139). Electrical performance remained stable, with 98% of retained leads maintaining capture thresholds \u2264\u20092\u2009V and 92% with sensed amplitudes \u2265\u20095\u2009mV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LBBAP using the INGEVITY\u2009+\u2009SDL is feasible and safe in clinical practice, with excellent implant success and stable mid\u2010term electrical performance. These findings support its use as a viable conduction system pacing strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70237","type":"journal-article","created":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T07:06:07Z","timestamp":1766905567000},"page":"475-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Implantation Success, Electrical Performance, and Safety of an Active Fixation Stylet\u2010Driven Lead for LBBAP in Clinical Practice: A Multicenter Experience"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2629-4372","authenticated-orcid":false,"given":"Amato","family":"Santoro","sequence":"first","affiliation":[{"name":"Azienda Ospedaliera Universitaria Senese Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Ziacchi","sequence":"additional","affiliation":[{"name":"S. Orsola\u2010Malpighi University Hospital University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimondo","family":"Calvanese","sequence":"additional","affiliation":[{"name":"Ospedale del Mare Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Rapacciuolo","sequence":"additional","affiliation":[{"name":"Federico II University of Naples Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Volpicelli","sequence":"additional","affiliation":[{"name":"Ospedale Santa Maria della Piet\u00e0 Nola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Poggio","sequence":"additional","affiliation":[{"name":"Ospedale Maggiore di Lodi Lodi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Nocerino","sequence":"additional","affiliation":[{"name":"Presidio Ospedaliero Santa Maria delle Grazie Pozzuoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Castagno","sequence":"additional","affiliation":[{"name":"A.O.U. Citta della Salute e della Scienza di Torino Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valter","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera dei Colli Ospedale Monaldi Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4370-891X","authenticated-orcid":false,"given":"Paolo Liberato","family":"Magliano","sequence":"additional","affiliation":[{"name":"\u201cS. Giovanni Bosco\u201d Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7517-0771","authenticated-orcid":false,"given":"Gabriele","family":"Dell'Era","sequence":"additional","affiliation":[{"name":"AOU Maggiore della Carit\u00e0 Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosimo","family":"Mandurino","sequence":"additional","affiliation":[{"name":"\u201cSS. Annunziata\u201d Hospital Taranto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Mirizzi","sequence":"additional","affiliation":[{"name":"Fondazione Toscana \u201cGabriele Monasterio\u201d CNR Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Savarese","sequence":"additional","affiliation":[{"name":"\u201cS. Giovanni Battista\u201d Hospital Foligno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Marinaccio","sequence":"additional","affiliation":[{"name":"Immacolata Concezione Hospital Piove di Sacco Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2692-7333","authenticated-orcid":false,"given":"Carmelo","family":"La Greca","sequence":"additional","affiliation":[{"name":"Fondazione Poliambulanza Hospital Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"Covino","sequence":"additional","affiliation":[{"name":"\u201cS. Giovanni di Dio\u201d Hospital Frattamaggiore Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Zingarini","sequence":"additional","affiliation":[{"name":"\u201cS. Maria della Misericordia\u201d Hospital Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Varalda","sequence":"additional","affiliation":[{"name":"\u201cSS. 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