{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:23:54Z","timestamp":1777735434226,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Multifocal ectopic Purkinje\u2010related premature contractions (MEPPC) is a syndrome caused by gain\u2010of\u2010function SCN5A variants, characterized by multifocal ventricular ectopy and dilated cardiomyopathy (DCM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>We report a case of a 63\u2010year\u2010old woman with longstanding DCM and a high burden of multifocal premature ventricular contractions arising from the His\u2013Purkinje system, refractory to multiple antiarrhythmic drugs and associated with progressive heart failure. Genetic testing identified the pathogenic SCN5A R814W variant. Quinidine resulted in complete suppression of ventricular ectopy, marked improvement in left ventricular function, and clinical recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case supports the role of a rare SCN5A variant in MEPPC and the efficacy of quinidine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70238","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T10:37:23Z","timestamp":1768905443000},"page":"663-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SCN5A R814W\u2010Associated Multifocal Ventricular Ectopy and Dilated Cardiomyopathy: A Treatable Channelopathy"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8753-4615","authenticated-orcid":false,"given":"Marta Catarina","family":"Bernardo","sequence":"first","affiliation":[{"name":"Cardiology Department Local Health Unit of Tr\u00e1s\u2010os\u2010Montes e Alto\u2010Douro Vila Real Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel Martins","family":"Moreira","sequence":"additional","affiliation":[{"name":"Cardiology Department Local Health Unit of Tr\u00e1s\u2010os\u2010Montes e Alto\u2010Douro Vila Real Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7423-231X","authenticated-orcid":false,"given":"Jos\u00e9 Pedro","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Cardiology Department Local Health Unit of Tr\u00e1s\u2010os\u2010Montes e Alto\u2010Douro Vila Real Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2434-6570","authenticated-orcid":false,"given":"Renato","family":"Margato","sequence":"additional","affiliation":[{"name":"Cardiology Department Local Health Unit of Tr\u00e1s\u2010os\u2010Montes e Alto\u2010Douro Vila Real Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Borges","sequence":"additional","affiliation":[{"name":"Cardiology Department Local Health Unit of Tr\u00e1s\u2010os\u2010Montes e Alto\u2010Douro Vila Real Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia Silva","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Cardiology Department Local Health Unit of Tr\u00e1s\u2010os\u2010Montes e Alto\u2010Douro Vila Real Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Il\u00eddio","family":"Moreira","sequence":"additional","affiliation":[{"name":"Cardiology Department Local Health Unit of Tr\u00e1s\u2010os\u2010Montes e Alto\u2010Douro Vila Real Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.09.084"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.02.052"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.164673"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2024.102223"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12993"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.113.000578"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2023.08.029"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00301"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-018-0599-4"}],"container-title":["Journal of Cardiovascular 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