{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:29:59Z","timestamp":1792214999859,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n AVEIR DR, an industry\u2010first dual\u2010chamber leadless pacemaker (LP), provides continuous atrioventricular synchrony through implant\u2010to\u2010implant (i2i) communication between atrial and ventricular LP devices. It is important to evaluate the early real\u2010world comparative safety of AVEIR DR LP.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To compare complications and mortality between AVEIR DR LP and dual\u2010chamber transvenous pacemakers (TP).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n De novo LP and TP patients were identified in Medicare Fee\u2010for\u2010Service claims (October 2023 and December 2024). Outcomes were 30\u2010day and 6\u2010month complications, reinterventions, heart failure hospitalizations, and all\u2010cause mortality. Comparisons were adjusted for demographics, comorbidities, and hospital encounter characteristics.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared to TP (\n N<\/jats:italic>\n \u2009=\u200977\u2009422, age\u2009=\u200979.6\u2009\u00b1\u20097.5), LP patients (\n N<\/jats:italic>\n \u2009=\u2009759, age\u2009=\u200978.5\u2009\u00b1\u20097.8) had a higher comorbidity index, more dialysis dependence, end\u2010stage renal disease, and atrial fibrillation. Adjusted 30\u2010day overall complications (7.9% vs. 9.2%; odds ratio [OR] 0.85,\n p<\/jats:italic>\n \u2009=\u20090.36) and mortality (1.8% vs. 1.5%; hazard ratio [HR] 1.21,\n p<\/jats:italic>\n \u2009=\u20090.47) were comparable, while device\u2010related complications (2.0% vs. 3.9%; OR 0.50,\n p<\/jats:italic>\n \u2009<\u20090.01) were lower with LP. Adjusted 6\u2010month overall complications (4.1% vs. 6.9%; HR 0.59,\n p<\/jats:italic>\n \u2009<\u20090.01), device\u2010related complications (2.8% vs. 5.9%; HR 0.48,\n p<\/jats:italic>\n \u2009<\u20090.01), and device reinterventions (2.1% vs. 4.3%; HR 0.49,\n p<\/jats:italic>\n \u2009<\u20090.01) were reduced with LP, with no difference in mortality (6.6% vs. 5.6%; HR 1.18,\n p<\/jats:italic>\n \u2009=\u20090.43) and heart failure hospitalizations (3.8% vs. 4.1%; HR 0.91,\n p<\/jats:italic>\n \u2009=\u20090.65).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Despite a higher comorbidity burden, AVEIR DR LP had significantly fewer device\u2010related complications, overall 6\u2010month complications, and device reinterventions compared to TP, with similar overall 30\u2010day complications, mortality, and heart failure hospitalizations.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jce.70255","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:52:19Z","timestamp":1768560739000},"page":"544-553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Leadless Versus Transvenous Dual\u2010Chamber Pacemakers: Real\u2010World Evidence From AVEIR DR Coverage With Evidence Development Study"],"prefix":"10.1111","volume":"37","author":[{"given":"Monica","family":"Lo","sequence":"first","affiliation":[{"name":"Arkansas Heart Hospital Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6432-1573","authenticated-orcid":false,"given":"Anish K.","family":"Amin","sequence":"additional","affiliation":[{"name":"OhioHealth Heart and Vascular Physicians Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Zucker School of Medicine at Hofstra\/Northwell Hempstead New York USA"},{"name":"Staten Island University Hospital, Northwell Health Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kroman","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilip","family":"Mathew","sequence":"additional","affiliation":[{"name":"Sarasota Memorial Hospital Sarasota Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valay","family":"Parikh","sequence":"additional","affiliation":[{"name":"Zucker School of Medicine at Hofstra\/Northwell Hempstead New York USA"},{"name":"Staten Island University Hospital, Northwell Health Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Weiner","sequence":"additional","affiliation":[{"name":"Christus Health Tyler Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Joseph","sequence":"additional","affiliation":[{"name":"Abbott Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Ganz","sequence":"additional","affiliation":[{"name":"Abbott Sylmar California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Mortada","sequence":"additional","affiliation":[{"name":"Aurora St. Luke's Medical Center Milwaukee Wisconsin USA"},{"name":"Wake Forest University School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"AVEIR DR Study Group\/Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.12.014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16688"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2300080"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.069006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.04.091"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.04.002"},{"key":"e_1_2_9_8_1","unstructured":"\u201cVEIR DR Coverage With Evidence Development (CED) Study \u201d ClinicalTrials.gov identifier: NCT05932602 accessed April 9 2025 https:\/\/clinicaltrials.gov\/study\/NCT05932602?intr=Aveir%20DR%20Leadless%20Pacemaker%20System&rank=2."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwy201"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euae257"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.03.1816"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.70056.Epub"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.03.019"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2021.2621"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.125.042471"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euae273"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.06.008"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2023.09.017"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15343"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2308353"},{"key":"e_1_2_9_22_1","unstructured":"\u201cLeadless Pacing Systems: Risk of Major Complications Related to Cardiac Perforation During Implantation \u201d Letter to Health Care Providers 2021."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13140"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.70255","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:13:26Z","timestamp":1777461206000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.70255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,16]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/jce.70255"],"URL":"https:\/\/doi.org\/10.1111\/jce.70255","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,16]]},"assertion":[{"value":"2025-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}