{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:33:50Z","timestamp":1790480030000,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pulsed field ablation (PFA) is a novel, non\u2010thermal ablation modality to achieve pulmonary vein isolation (PVI) for the treatment of atrial fibrillation (AF). For the pentaspline catheter, eight applications per pulmonary vein (PV) are considered standard, with four in basket configuration and four in flower configuration. The objective of the study is to investigate whether pentaspline PFA using 16 applications per PV is associated with an improved outcome compared with the standard procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The prospective study included a total of 292 patients with AF. According to the number of applications per PV, patients were assigned to group PFA\u20108 (8 applications per PV; 4x basket configuration, 4x flower configuration;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009130) or group PFA\u201016 (16 applications per PV; 6x basket, 10x flower;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009162). The primary endpoint was freedom from atrial arrhythmia (AA), i.e. AF, atrial flutter, and atrial tachycardia, after a follow\u2010up period of 1 year, as assessed by Holter monitoring after 3 and 12 months, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Freedom from AA was significantly higher in group PFA\u201016 than in group PFA\u20108 (73.9% vs. 62.3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Subgroup analysis showed greater effectiveness in the PFA\u201016 group than in the PFA\u20108 group (66.1% vs. 45.3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) in patients with persistent AF, while freedom from AA was similar in both groups in patients with paroxysmal AF (78.8% in PFA\u201016 vs. 75.7% in PFA\u20108;\n                      <jats:italic>p\u2009<\/jats:italic>\n                      =\u2009ns). Serious adverse events were observed in 8 (2.7%) patients, with no differences between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PVI using 16 PFA applications per PV may improve clinical outcome in patients with persistent AF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70266","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:14:37Z","timestamp":1768968877000},"page":"583-592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Pulsed Field Ablation Dosing on Outcome After Pulmonary Vein Isolation Using a Pentaspline Ablation Catheter: A Prospective Comparison of 8 Versus 16 Applications"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0368-2914","authenticated-orcid":false,"given":"Katharina Ji\u2010Mi","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty University Hospital Duesseldorf, Heinrich\u2010Heine University Duesseldorf Duesseldorf Nordrhein\u2010Westfalen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Spieker","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty University Hospital Duesseldorf, Heinrich\u2010Heine University Duesseldorf Duesseldorf Nordrhein\u2010Westfalen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Angendohr","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty University Hospital Duesseldorf, Heinrich\u2010Heine University Duesseldorf Duesseldorf Nordrhein\u2010Westfalen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"auf der Heiden","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty University Hospital Duesseldorf, Heinrich\u2010Heine University Duesseldorf Duesseldorf Nordrhein\u2010Westfalen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gl\u00f6ckner","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty University Hospital Duesseldorf, Heinrich\u2010Heine University Duesseldorf Duesseldorf Nordrhein\u2010Westfalen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Sansone","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty University Hospital Duesseldorf, Heinrich\u2010Heine University Duesseldorf Duesseldorf Nordrhein\u2010Westfalen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Kelm","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty University Hospital Duesseldorf, Heinrich\u2010Heine University Duesseldorf Duesseldorf Nordrhein\u2010Westfalen Germany"},{"name":"Cardiovascular Research Institute Duesseldorf, Medical Faculty Heinrich\u2010Heine University Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4820-3304","authenticated-orcid":false,"given":"Alexandru Gabriel","family":"Bejinariu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty University Hospital Duesseldorf, Heinrich\u2010Heine University Duesseldorf Duesseldorf Nordrhein\u2010Westfalen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obaida","family":"Rana","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty University Hospital Duesseldorf, Heinrich\u2010Heine University Duesseldorf Duesseldorf Nordrhein\u2010Westfalen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001193"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae176"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2018.06.005"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.021"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab090"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16132"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307291"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2502280"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.123.011920"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16101"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2021.02.014"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.11.031"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2025.02.026"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16187"},{"key":"e_1_2_11_16_1","first-page":"103","article-title":"The US4ABL Strategy: A Systematic Ultrasound\u2010Guided Approach for Left Atrial and Ventricular Ablation Procedures","volume":"14","author":"Bejinariu A. G.","year":"2025","journal-title":"J Clin Med Multidisciplinary Digital Publishing Institute"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000509399"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"e_1_2_11_20_1","first-page":"635","article-title":"IFCC Primary Reference Procedures for the Measurement of Catalytic Activity Concentrations of Enzymes at 37\u00b0C. Part 2. Reference Procedure for the Measurement of Catalytic Concentration of Creatine Kinase","volume":"40","author":"Schumann G.","year":"2002","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.132654"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.123.012667"},{"key":"e_1_2_11_23_1","article-title":"Effect of Fibrosis Regionality on Atrial Fibrillation Recurrence: Insights From DECAAF II","volume":"25","author":"Assaf A.","year":"2023","journal-title":"Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000922"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1217745"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2024.05.001"},{"key":"e_1_2_11_27_1","article-title":"Severe Acute Kidney Injury Related to Haemolysis After Pulsed Field Ablation for Atrial Fibrillation","volume":"26","author":"Venier S.","year":"2024","journal-title":"EP Eur"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.124.012732"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03114-3"},{"issue":"125","key":"e_1_2_11_30_1","article-title":"Hemolysis After Pulsed Field Ablation in Pulmonary Vein Isolation for Atrial Fibrillation: A Prospective Controlled Trial","volume":"1547","author":"Heiden C.","year":"2025","journal-title":"Heart Rhythm: The Official Journal of the Heart Rhythm Society"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.124.012732"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.70266","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:13:08Z","timestamp":1777461188000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.70266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,20]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/jce.70266"],"URL":"https:\/\/doi.org\/10.1111\/jce.70266","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,20]]},"assertion":[{"value":"2025-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}