{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:01:15Z","timestamp":1780498875029,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000046","name":"Abbott Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The response to cardiac resynchronization therapy (CRT) can depend on when and where the right and left ventricles (RV, LV) are paced. Dynamic atrioventricular (AV) delays (SyncAV CRT, Abbott) and multi\u2010site LV pacing (e.g., MultiPoint Pacing [MPP], Abbott) are features that may enhance CRT response. Their combined impact has not been evaluated in a chronic clinical setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Evaluate the 6\u2010month echocardiographic and clinical response to SyncAV when combined with either biventricular MPP (MPP+SyncAV: RV\u2009+\u2009LV1\u2009+\u2009LV2 pacing) or LV\u2010only MPP (LVMPP+SyncAV: LV1\u2009+\u2009LV2 pacing).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CRT\u2010indicated patients with LBBB and intact AV conduction (PR\u2009&lt;\u2009250\u2009ms) were implanted and randomized to either MPP+SyncAV or LVMPP+SyncAV in an international, multi\u2010center clinical study. Patient\u2010specific SyncAV offsets were selected to minimize QRS duration at implant. The following response metrics were captured at baseline and 6 months post\u2010implant: LV end\u2010systolic volume (ESV), LV ejection fraction (EF), NYHA class, quality of life score (QoL), and Packer score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CRT implant and 6\u2010month visits were completed in 70 patients (69 years old, 73% male, 179\u2009ms PR, 164\u2009ms QRS). MPP+SyncAV (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936) and LVMPP+SyncAV (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934) groups demonstrated comparable 6\u2010month response magnitudes and responder rates for \u0394ESV\u2009\u2264\u2009\u221215% (85% vs. 74%) and \u0394EF\u2009\u2265\u20095% (94% vs. 77%), as well as improvements in NYHA class (43% vs. 47%), QoL (59% vs. 64%), and Packer score (70% vs. 70%);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05 for all.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The 6\u2010month echocardiographic (ESV, EF) and clinical (NYHA class, QoL, Packer) response rates observed in LBBB patients were promising when SyncAV was combined with MPP, in both biventricular and LV\u2010only pacing modes.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      NCT03567096.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70294","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:08:37Z","timestamp":1773011317000},"page":"811-819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Left Ventricular and Biventricular Multipoint Pacing With Dynamic Atrioventricular Delays: 6\u2010Month Cardiac Resynchronization Therapy Response"],"prefix":"10.1111","volume":"37","author":[{"given":"Bernard","family":"Thibault","sequence":"first","affiliation":[{"name":"From the Electrophysiology Service, Montreal Heart Institute Universit\u00e9 de Montr\u00e9al Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6368-8178","authenticated-orcid":false,"given":"Peter","family":"Waddingham","sequence":"additional","affiliation":[{"name":"Barts Heart Centre St. Bartholomew's Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Badie","sequence":"additional","affiliation":[{"name":"Abbott Sylmar California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan O.","family":"Mangual","sequence":"additional","affiliation":[{"name":"Abbott Sylmar California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis\u2010Philippe","family":"Richer","sequence":"additional","affiliation":[{"name":"Abbott Sylmar California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke C.","family":"McSpadden","sequence":"additional","affiliation":[{"name":"Abbott Sylmar California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim R.","family":"Betts","sequence":"additional","affiliation":[{"name":"Cardiology Department Oxford University Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Cal\u00f2","sequence":"additional","affiliation":[{"name":"Policlinico Casilino Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Grieco","sequence":"additional","affiliation":[{"name":"Policlinico Casilino Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Leyva","sequence":"additional","affiliation":[{"name":"Aston Medical Research Institute Aston Medical School Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Chow","sequence":"additional","affiliation":[{"name":"Barts Heart Centre St. Bartholomew's Hospital London 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