{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:01:17Z","timestamp":1780498877046,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>A lower frequency early electrogram (EGM) or broad area of early activation during premature ventricular contraction (PVC) mapping may be associated with a PVC origin in an opposing chamber or deep within the mapped surface. The utility of quantifying EGM frequency at early activation sites and isochronal activated surface area (IASA) is unclear. Our study aimed to investigate the utility of EGM frequency analysis and IASA mapping to complement activation mapping during PVC ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>High density PVC activation and IASA maps were created using a multi\u2010electrode mapping catheter in 25 patients undergoing PVC ablation. EGMs in early activation regions were retrospectively studied. IASAs in each mapped chamber were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ablation success was achieved in 18 of 25 (72%) patients. Ablation was successful in all patients with EGM frequency &gt;\u2009325\u2009Hz (local activation time (LAT) range 28\u201354\u2009ms) and in all patients with pre\u2010QRS LAT\u2009&gt;\u200940\u2009ms (EGM frequency range 127\u2013563\u2009Hz). In patients with pre\u2010QRS LAT\u2009&lt;\u200940\u2009ms and EGM frequency &lt;\u2009325\u2009Hz, ablation was successful in 9 of 16 cases (56%). Mean IASA mapped within 10\u2009ms was smaller at successful ablation sites compared to opposing chambers (0.33 vs 0.95\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). All ablation in chambers with IASA\u2009&gt;\u20091.5\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      within 10\u2009ms was unsuccessful.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher EGM frequency and smaller IASA were associated with successful ablation of PVCs. Ablation at sites with EGM frequency &gt;\u2009325\u2009Hz was successful in all patients. The utility of identifying higher frequency EGMs at early activation sites requires further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70296","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:03:30Z","timestamp":1772985810000},"page":"820-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electrogram Frequency Analysis and Isochronal Activation Surface Area Mapping for Ablation of Premature Ventricular Contractions"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1701-3572","authenticated-orcid":false,"given":"Michael A.","family":"Hoffer\u2010Hawlik","sequence":"first","affiliation":[{"name":"Leon H. Charney Division of Cardiology New York University Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyna","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Abbott New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Rosinski","sequence":"additional","affiliation":[{"name":"Abbott New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Jankelson","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology New York University Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kushnir","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology New York University Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Garber","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology New York University Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Holmes","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology New York University Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Aizer","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology New York University Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4454-6761","authenticated-orcid":false,"given":"Larry A.","family":"Chinitz","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology New York University Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3479-936X","authenticated-orcid":false,"given":"Chirag R.","family":"Barbhaiya","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology New York University Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.04.039"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2023.10.014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/cdbme-2021-2045"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2024.02.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.16-552"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2009.01566.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.11.011"},{"key":"e_1_2_9_9_1","article-title":"Best Ablation Strategy in Patients with Premature Ventricular Contractions with Multiple Morphology: A Single\u2010Centre Experience","volume":"25","author":"Mohanty S.","year":"2023","journal-title":"Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13817"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2019.6.2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15114"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23578"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13491"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.12.029"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.969592"},{"key":"e_1_2_9_17_1","article-title":"New Peak Frequency Maps\u2019 Usefulness to Enhance Localization and Ablation of Premature Ventricular Contractions","volume":"27","author":"Spera F.","year":"2025","journal-title":"Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70296","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.70296","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:02:50Z","timestamp":1780495370000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.70296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/jce.70296"],"URL":"https:\/\/doi.org\/10.1111\/jce.70296","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]},"assertion":[{"value":"2025-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}