{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:14:07Z","timestamp":1779106447923,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In the CAPLA trial, arrhythmia\u2010free survival did not differ between patients with persistent atrial fibrillation (AF) who underwent pulmonary vein isolation (PVI) with posterior wall isolation (PWI) vs. PVI alone. High AF polygenic risk scores (PRS) have been associated with increased left atrial substrate and arrhythmia recurrence post\u2010ablation. Whether AF patients with high AF\u2010PRS benefit from a more extensive ablation strategy (PVI with PWI) is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the impact of adjunctive PWI on ablation outcomes in patients with persistent AF stratified by AF\u2010PRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Genome\u2010wide genotyping was performed in a CAPLA trial subgroup and a previously validated AF\u2010PRS was derived. The primary endpoint was freedom from documented atrial arrhythmia with or without the use of antiarrhythmic drugs at 3 years after a single ablation procedure in patients with high AF\u2010PRS who underwent PVI with PWI vs. PVI alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and seventy\u2010four patients (75.29% male, median age 66.70 years) were evaluated. Mean AF\u2010PRS was significantly higher than in a control cohort of healthy individuals (30.23 vs. 30.15;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Amongst patients with high AF\u2010PRS (defined by AF\u2010PRS corresponding to the top quartile of control cohort scores), there were no significant differences between patients who underwent PVI with PWI (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936) vs. PVI only (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200949) with respect to atrial arrhythmia\u2010free survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.883), arrhythmia burden (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.772) or quality\u2010of\u2010life scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.794) over median follow\u2010up of 3.76 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with persistent AF undergoing ablation, the addition of PWI to PVI in those with high AF\u2010PRS did not significantly improve long\u2010term ablation outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70297","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:05:04Z","timestamp":1772978704000},"page":"917-924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Are Genetics Useful to Guide Ablation Strategies in Patients With Persistent Atrial Fibrillation?"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9564-5271","authenticated-orcid":false,"given":"Michael W.","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Cardiology Royal Melbourne Hospital, Parkville Victoria Australia"},{"name":"Heart Centre, The Alfred Hospital, Melbourne Victoria Australia"},{"name":"Department of Medicine University of Melbourne, Melbourne Victoria Australia"},{"name":"Baker Heart and Diabetes Research Institute, Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5369-5844","authenticated-orcid":false,"given":"Peter M.","family":"Kistler","sequence":"additional","affiliation":[{"name":"Heart Centre, The Alfred Hospital, Melbourne Victoria Australia"},{"name":"Department of Medicine University of Melbourne, Melbourne Victoria Australia"},{"name":"Baker Heart and Diabetes Research Institute, Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie G.","family":"Curtin","sequence":"additional","affiliation":[{"name":"Heart Centre, The Alfred Hospital, Melbourne Victoria Australia"},{"name":"Baker Heart and Diabetes Research Institute, Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Chieng","sequence":"additional","affiliation":[{"name":"Heart Centre, The Alfred Hospital, Melbourne Victoria Australia"},{"name":"Baker Heart and Diabetes Research Institute, Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"William","sequence":"additional","affiliation":[{"name":"Heart Centre, The Alfred Hospital, Melbourne Victoria Australia"},{"name":"Department of Medicine University of Melbourne, Melbourne Victoria Australia"},{"name":"Baker Heart and Diabetes Research Institute, Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Segan","sequence":"additional","affiliation":[{"name":"Heart Centre, The Alfred Hospital, Melbourne Victoria Australia"},{"name":"Department of Medicine University of Melbourne, Melbourne Victoria Australia"},{"name":"Baker Heart and Diabetes Research Institute, Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Crowley","sequence":"additional","affiliation":[{"name":"Heart Centre, The Alfred Hospital, Melbourne Victoria Australia"},{"name":"Department of Medicine University of Melbourne, Melbourne Victoria Australia"},{"name":"Baker Heart and Diabetes Research Institute, Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena J.","family":"Soka","sequence":"additional","affiliation":[{"name":"Victor Chang Cardiac Research Institute Darlinghurst New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul E.","family":"Young","sequence":"additional","affiliation":[{"name":"Victor Chang Cardiac Research Institute Darlinghurst New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma M.","family":"Rath","sequence":"additional","affiliation":[{"name":"Victor Chang Cardiac Research Institute Darlinghurst New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenglong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine, Monash University, Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Ohanian","sequence":"additional","affiliation":[{"name":"Victor Chang Cardiac Research Institute Darlinghurst New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee","family":"Johnson","sequence":"additional","affiliation":[{"name":"Victor Chang Cardiac Research Institute Darlinghurst New South Wales Australia"},{"name":"School of Clinical Medicine Faculty of Medicine and Health, UNSW Sydney Kensington New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0902-6798","authenticated-orcid":false,"given":"Paul","family":"Lacaze","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine, Monash University, Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Giannoulatou","sequence":"additional","affiliation":[{"name":"Victor Chang Cardiac Research Institute Darlinghurst New South Wales Australia"},{"name":"School of Clinical Medicine Faculty of Medicine and Health, UNSW Sydney Kensington New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandr","family":"Voskoboinik","sequence":"additional","affiliation":[{"name":"Heart Centre, The Alfred Hospital, Melbourne Victoria Australia"},{"name":"Baker Heart and Diabetes Research Institute, Melbourne 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