{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:14:07Z","timestamp":1779106447916,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K12254"],"award-info":[{"award-number":["25K12254"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Risk stratification in Brugada syndrome (BrS) remains challenging. Although spontaneous Type 1 ECG and clinical history (e.g., prior ventricular fibrillation [VF] or syncope) are established risk markers, additional electrocardiographic predictors are needed to refine prognostication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed 82 consecutive BrS patients referred to Oita University Hospital. After excluding 20 patients with drug\u2010induced and 2 with fever\u2010induced Type 1 ECG, 60 patients with spontaneous Type 1 Brugada ECG were included. The maximum coved\u2010type ST\u2010segment area (mV\u00b7ms) was quantified across leads V1\u2013V3 at standard and high\u2010intercostal positions. Patients were categorized into VF\u2010occurrence (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924) and non\u2010occurrence (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936) groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a mean follow\u2010up of 67\u2009\u00b1\u200959 months, 24 patients (40%) experienced VF. The maximum coved\u2010type ST\u2010segment area was significantly smaller in the VF\u2010occurrence group compared with the non\u2010occurrence group (27.7\u2009\u00b1\u200914.8 vs. 37.5\u2009\u00b1\u200916.7\u2009mV\u00b7ms;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022). In multivariate analysis, inferolateral J waves (OR 11.1; 95% CI 2.85\u201342.8;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and a small maximum coved\u2010type ST\u2010segment area (OR 5.47; 95% CI 1.17\u201325.7;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) were independent predictors of VF. Kaplan\u2013Meier analysis showed significantly lower VF\u2010free survival in patients with a small maximum coved\u2010type ST\u2010segment area (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with spontaneous Type 1 BrS, a small coved\u2010type ST\u2010segment area may be independently associated with VF and may represent a potential electrocardiographic marker for risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70305","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:44:05Z","timestamp":1772981045000},"page":"909-916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Small Coved\u2010Type ST\u2010Segment Area in Patients With Spontaneous Type 1 Brugada Syndrome"],"prefix":"10.1111","volume":"37","author":[{"given":"Nario","family":"Sano","sequence":"first","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine Oita University Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6106-6017","authenticated-orcid":false,"given":"Tetsuji","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine Oita University Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Yonezu","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine Oita University Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine Oita University Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirochika","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine Oita University Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Hirota","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine Oita University Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2451-5845","authenticated-orcid":false,"given":"Hidekazu","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine Oita University Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1670-6433","authenticated-orcid":false,"given":"Akira","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine Oita University Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidefumi","family":"Akioka","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine Oita University Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Teshima","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine Oita University Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology 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