{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:14:08Z","timestamp":1779106448628,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Ultra\u2010low Temperature Cryoablation (ULTC) using nitrogen cryogen near its boiling temperature of \u2212196\u00b0C is a novel cardiac ablation modality capable of producing titratable lesions with depth exceeding 10\u2009mm and has been recently introduced for catheter treatment of drug\u2010refractory ventricular tachycardia (VT). The ablative action of ULTC can be further augmented by the expansion of the cryogen within the ablation element yielding even lower ablation temperatures while optimizing mechanical handling characteristics of the catheter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The purpose of this report is to assess the feasibility and document the first pre\u2010clinical experience with acute endocardial lesion formation using augmented ultra\u2010low temperature cryoablation in healthy porcine models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A modified commercially available catheter was used to create 35 augmented ULTC lesions in four acute porcine and ovine models with energy applications durations ranging from 15 to 120\u2009s. Lesion depth and morphology were evaluated on gross necropsy and histopathology, using Masson's trichrome staining. Lesion depth ranged from median of 5.0 to median of 12.5\u2009mm, depending on ablation duration (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), with frequent transmurality and lesion morphology exhibiting consistent features across the depth range. The post\u2010ablation cardiac electrograms were reduced up to 89.4% in lesions with depth exceeding 10\u2009mm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Augmented ULTC can be implemented using a catheter with physical handling characteristics similar to contemporary RF catheters and may allow significant reduction in ablation time compared to conventional ULTC for the equivalent lesion depth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70311","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:41:08Z","timestamp":1773808868000},"page":"943-948","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Initial Pre\u2010Clinical Evaluation of the Augmented Ultra\u2010Low Temperature Cryoablation Catheter for Ventricular Ablations"],"prefix":"10.1111","volume":"37","author":[{"given":"Katia","family":"Dyrda","sequence":"first","affiliation":[{"name":"Montreal Heart Institute Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Verma","sequence":"additional","affiliation":[{"name":"McGill University Health Centre Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borislav","family":"Dinov","sequence":"additional","affiliation":[{"name":"University Hospital of Giessen, Justus Liebig University Giessen Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Fink","sequence":"additional","affiliation":[{"name":"Herz\u2010 und Diabeteszentrum NRW, Ruhr\u2010Universit\u00e4t Bochum Bad Oeynhausen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom De","family":"Potter","sequence":"additional","affiliation":[{"name":"Cardiovascular Center AZORG Aalst Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santi","family":"Raffa","sequence":"additional","affiliation":[{"name":"Zentralklinik Bad Berka GmbH Bad Berka Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Sirois","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Elaine","family":"Clavet\u2010Lanthier","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9749-6278","authenticated-orcid":false,"given":"Ilya","family":"Grigorov","sequence":"additional","affiliation":[{"name":"Adagio Medical, Inc. Laguna Hills California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedram","family":"Pourfard","sequence":"additional","affiliation":[{"name":"Adagio Medical, Inc. Laguna Hills California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Babkin","sequence":"additional","affiliation":[{"name":"Adagio Medical, Inc. Laguna Hills California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidal","family":"Essebag","sequence":"additional","affiliation":[{"name":"McGill University Health Centre Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2022.05.017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euae076"},{"issue":"2","key":"e_1_2_9_4_1","article-title":"Ultra Low Cryoablation for Scar\u2010Related VT Ablation: Results From the US Early Feasibility Study","volume":"19","author":"Weiss J. 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