{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:14:09Z","timestamp":1779106449614,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Intravenous lidocaine is frequently used for refractory ventricular arrhythmia (VA). Atrial fibrillation (AF) is a common comorbidity in VA patients. Lidocaine poses theoretical risks of hemodynamic compromise and pro\u2010arrhythmia, including AF with rapid ventricular rates (RVR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational study reviewed electronic medical records of AF patients receiving lidocaine for VA at University of Utah Hospital (April 2014\u2013October 2023). Hemodynamic parameters and cardiovascular outcomes were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      192 patients (mean age 63.6 years, 79% male) with predominantly paroxysmal AF (71%) were included. 79% had heart failure (HF), 53% ischemic, with a mean ejection fraction 31.7%. There was no difference in heart rate (\u22120.6\u2009\u00b1\u200931.6;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.4067), but systolic blood pressure and mean arterial pressure decreased on lidocaine vs baseline (\u22124.7\u2009\u00b1\u200922.6;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0367 and \u22124.8\u2009\u00b1\u200918.6;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0013, respectively). A single patient had AF with RVR attributed to lidocaine with no significant difference in AF with RVR on baseline vs lidocaine ECG (16, 9% vs 8, 6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.3957). Peak lidocaine levels (median 4.3\u2009mcg\/mL; IQR 3.0\u20135.8\u2009mcg\/mL) were not correlated with RVR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.9662). Adverse effects occurred in 7%, mainly central nervous system effects, with no clinically significant hypotension or worsening HF. In\u2010hospital mortality was 31%. Ischemic cardiomyopathy vs non\u2010ischemic cardiomyopathy was associated with increased mortality (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0162).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lidocaine for VA in AF patients had mild hemodynamic impacts without clinically significant hypotension or worsening HF. The risk of AF pro\u2010arrhythmia was low. Lidocaine use was associated with a high\u2010risk population with high in\u2010hospital mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70321","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:50:19Z","timestamp":1773982219000},"page":"962-968","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemodynamic Consequences and Clinical Outcomes With Intravenous Lidocaine Infusion in Patients With Atrial Fibrillation"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4198-5331","authenticated-orcid":false,"given":"Andrea N.","family":"Keithler","sequence":"first","affiliation":[{"name":"Department of Clinical Cardiac Electrophysiology Division of Cardiovascular Medicine University of Utah Health Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zameer","family":"Abedin","sequence":"additional","affiliation":[{"name":"Department of Clinical Cardiac Electrophysiology Division of Cardiovascular Medicine University of Utah Health Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Furman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Utah Health Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Utah Health Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc C.","family":"Engels","sequence":"additional","affiliation":[{"name":"Department of Clinical Cardiac Electrophysiology Division of Cardiovascular Medicine University of Utah Health Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger A.","family":"Freedman","sequence":"additional","affiliation":[{"name":"Department of Clinical Cardiac Electrophysiology Division of Cardiovascular Medicine University of Utah Health Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klitos","family":"Konstantinidis","sequence":"additional","affiliation":[{"name":"Department of Clinical Cardiac Electrophysiology Division of Cardiovascular Medicine University of Utah Health Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Immo Lehmann","sequence":"additional","affiliation":[{"name":"Department of Clinical Cardiac Electrophysiology Division of Cardiovascular Medicine University of Utah Health Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Ranjan","sequence":"additional","affiliation":[{"name":"Department of Clinical Cardiac Electrophysiology Division of Cardiovascular Medicine University of Utah Health Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin A.","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Cardiac Electrophysiology Division of Cardiovascular Medicine University of Utah Health Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5349-0136","authenticated-orcid":false,"given":"T. Jared","family":"Bunch","sequence":"additional","affiliation":[{"name":"Department of Clinical Cardiac Electrophysiology Division of Cardiovascular Medicine University of Utah Health Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13650"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.50.6.1217"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.29.3.286"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.24.5.639"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106224"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(73)90011-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1950.02910430009003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.10.024"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.054"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(65)90054-8"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196910000-00006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(69)90403-2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.61.7.682"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.64719\/pb.4495"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)28937-6"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(77)80218-4"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2000.106169"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(78)90239-9"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70321","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.70321","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:26:26Z","timestamp":1779103586000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.70321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,19]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/jce.70321"],"URL":"https:\/\/doi.org\/10.1111\/jce.70321","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,19]]},"assertion":[{"value":"2025-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}