{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:43:27Z","timestamp":1791348207314,"version":"4.3.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Left bundle branch area pacing (LBBAP) is increasingly being used for cardiac resynchronization therapy (CRT); however an additional left ventricular (LV) lead is required when resynchronization remains incomplete. This study evaluates whether lead V8 can provide a simple, non\u2010invasive marker of persistent posterolateral LV delay during LBBAP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients undergoing LOT\u2010CRT implantation were included. Standard 12\u2010lead ECGs were obtained with the V5 electrode repositioned to the V8 location. Local activation time was measured as the steepest negative downslope of the QRS (negative derivative activation time, NDAT) and compared with the LV electrical delay (LVED) determined from the LV lead during LBBAP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty consecutive patients undergoing LOT\u2010CRT implantation were included with a total of 106 ECG recordings with corresponding LVED measurements. The NDAT\u2010V8 demonstrated a strong correlation with the LVED during intrinsic conduction (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.95) and during all LBB pacing subtypes: combined\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.922; mean difference 2.5\u2009\u00b1\u20098\u2009ms; RV septal pacing,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.89; LV septal pacing,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.92; non\u2010selective LBBP,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.91; and selective LBBP,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.81. The correlation of LVED during intrinsic conduction and all LBBAP pacing subtypes was significantly weaker for NDAT\u2010V6 and the RWPT in V6 and V8 (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.681, 0.626, and 0.726, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The NDAT\u2010V8 provides a reliable non\u2010invasive surrogate for the LV posterolateral wall delay during LBBAP, outperforming NDAT\u2010V6 and the RWPT in V6 and V8 and establishes the groundwork for future studies evaluating NDAT\u2010V8 as a tool to guide adequate resynchronization during LBBAP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70336","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T05:08:07Z","timestamp":1776402487000},"page":"1276-1285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Resynchronization Effect in Left Bundle Branch Pacing Can be Evaluated Non\u2010Invasively With the Implementation of Lead V8"],"prefix":"10.1111","volume":"37","author":[{"given":"Vadivelu","family":"Ramalingam","sequence":"first","affiliation":[{"name":"Department of Medicine McGill University Health Center Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan van","family":"Koll","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Medicine McGill University Health Center Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidal","family":"Essebag","sequence":"additional","affiliation":[{"name":"Department of Medicine McGill University Health Center Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Medicine McGill University Health Center Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uy\u00ean C.","family":"Nguy\u00ean","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8129-7384","authenticated-orcid":false,"given":"Joost","family":"Lumens","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin G. L. M.","family":"Luermans","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Vernooy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-688X","authenticated-orcid":false,"given":"Jacqueline","family":"Joza","sequence":"additional","affiliation":[{"name":"Department of Medicine McGill University Health Center Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad168"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.09.013"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac445"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf699"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2025.03.024"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.09.030"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16128"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.03.007"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.124.013059"},{"issue":"10","key":"e_1_2_13_11_1","article-title":"Left Bundle 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and the Latin American Heart Rhythm Society","volume":"27","author":"Glikson M.","year":"2025","journal-title":"Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2019.12"}],"container-title":["Journal of Cardiovascular 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