{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:54:30Z","timestamp":1781589270905,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The procedural complexity and outcomes of atrial fibrillation (AF) ablation in patients with sick sinus syndrome (SSS) remain unclear. This study aimed to evaluate procedural strategies, including pulmonary vein isolation (PVI) and additional ablation, and AF recurrence according to SSS status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      This retrospective study included 53 patients with SSS and 623 without SSS undergoing initial radiofrequency AF ablation. PVI\u2010plus ablation was defined as any ablation targeting the cavotricuspid isthmus (CTI) for common atrial flutter (AFL), non\u2010pulmonary vein (non\u2010PV) foci, or atrial tachycardia. PVI\u2010plus ablation and AF recurrence were compared using 1:5 propensity score matching (53 with SSS and 265 without SSS). PVI\u2010plus was more frequent in the SSS group than in the non\u2010SSS group (47% vs. 29%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), particularly CTI ablation (38% vs. 21%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) and non\u2010PV foci ablation (15% vs. 7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026). SSS was associated with higher odds of PVI\u2010plus (odds ratio 2.087; 95% CI, 1.146\u20133.787). AF recurrence at 36 months did not differ significantly between SSS and non\u2010SSS (42% vs. 31%; sHR 1.314; 95% CI, 0.812\u20132.127). During follow\u2010up, new permanent pacemaker implantation was required in seven SSS patients (13%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with SSS more frequently underwent PVI\u2010plus ablation for AFL or non\u2010PV foci, yet long\u2010term AF recurrence was comparable to that in non\u2010SSS patients, underscoring the importance of careful assessment for concomitant atrial arrhythmias in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70338","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:00:15Z","timestamp":1775908815000},"page":"1199-1207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Procedural Complexity and Outcomes of Catheter Ablation for Atrial Fibrillation in Patients With Sick Sinus Syndrome"],"prefix":"10.1111","volume":"37","author":[{"given":"Rikako","family":"Horie","sequence":"first","affiliation":[{"name":"Department of Cardiology, Pulmonology, Hypertension &amp; Nephrology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology, Hypertension &amp; Nephrology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisho","family":"Kurokawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology, Hypertension &amp; Nephrology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology, Hypertension &amp; Nephrology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology, Hypertension &amp; Nephrology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Ihara","sequence":"additional","affiliation":[{"name":"Clinical Research Promotion Unit, Clinical Therapeutic Trial Center Ehime University Hospital Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology, Hypertension &amp; Nephrology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuji","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology, Hypertension &amp; Nephrology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuntaro","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology, Hypertension &amp; Nephrology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology, Hypertension &amp; Nephrology Ehime University Graduate School of Medicine Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euae016"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.063988"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307291"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-15-1384"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.01.048"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2021.100717"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.10.033"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.05.003"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab161"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12681"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13721"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16734"},{"issue":"1","key":"e_1_2_12_14_1","first-page":"e1","article-title":"ACC\/AHA\/ACCP\/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"149","author":"Joglar J. 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