{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:24:09Z","timestamp":1792686249550,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pulsed field ablation (PFA) has emerged as a novel non\u2010thermal modality for atrial fibrillation (AF) ablation. While hemolysis is a known complication of PFA, comparative data among different systems remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively enrolled 150 consecutive AF patients undergoing ablation with one of three PFA systems: FARAPULSE (FP), PulseSelect (PS), or VARIPULSE (VP) (50 cases each). Perioperative blood samples were collected pre\u2010procedure, immediately post\u2010procedure, and at 24\u2009h. Hemolysis markers (LDH, LD2, indirect bilirubin, haptoglobin) and myocardial injury markers (CK, CK\u2010MB, troponin T) were measured. Procedural characteristics and complications were compared across the systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 144 analyzed patients, VP was associated with the shortest procedure time (76\u2009\u00b1\u200927\u2009min vs. FP 91\u2009\u00b1\u200925\u2009min and PS 97\u2009\u00b1\u200926\u2009min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and fewest applications (23\u2009\u00b1\u20095 vs. FP 40\u2009\u00b1\u20096 and PS 56\u2009\u00b1\u200926,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Hemolysis markers increased in all systems, but the magnitude varied. \u0394LDH was highest with FP (95.1\u2009\u00b1\u200949.4\u2009U\/L), intermediate with PS (62.6\u2009\u00b1\u200938.1\u2009U\/L), and lowest with VP (41.3\u2009\u00b1\u200926.7\u2009U\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Haptoglobin decreased most with FP (\u0394Hp \u221256.5\u2009\u00b1\u200927.2\u2009mg\/dL), followed by VP (\u221241.7\u2009\u00b1\u200925.8\u2009mg\/dL) and PS (\u221228.3\u2009\u00b1\u200921.6\u2009mg\/dL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Myocardial injury also differed: \u0394Troponin T was lowest with VP (1545\u2009\u00b1\u2009920\u2009pg\/mL vs. FP 2392\u2009\u00b1\u20091123\u2009pg\/mL and PS 2128\u2009\u00b1\u20091041\u2009pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), with a similar trend for \u0394CK (141\u2009\u00b1\u200992\u2009U\/L vs. 231\u2009\u00b1\u2009138\u2009U\/L and 207\u2009\u00b1\u2009119\u2009U\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Complications included acute kidney injury in two FP cases and cardiac tamponade in one PS case.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hemolysis and myocardial injury differ among PFA systems. FP was associated with the greatest changes, PS with the least hemolysis, and VP with the least myocardial injury. These differences may reflect variations in pulse output, electrode configuration, and tissue contact visualization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70343","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T11:56:11Z","timestamp":1775908571000},"page":"1249-1258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of HEMOlysis Markers Among Three Pulsed Field Ablation Systems: HEMO\u2010PFA Study"],"prefix":"10.1111","volume":"37","author":[{"given":"Kazuhisa","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Cardiology Saitama Medical University, International Medical Center Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saitama Medical University, International Medical Center Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saitama Medical University, International Medical Center Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1418-6566","authenticated-orcid":false,"given":"Wataru","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saitama Medical University, International Medical Center Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Naganuma","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saitama Medical University, International Medical Center Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0624-9639","authenticated-orcid":false,"given":"Masataka","family":"Narita","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saitama Medical University, International Medical Center Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1172-2995","authenticated-orcid":false,"given":"Hitoshi","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saitama Medical University, International Medical Center Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saitama Medical University, International Medical Center Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahide","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saitama Medical University, International Medical Center Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saitama Medical University, International Medical Center Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5648-8135","authenticated-orcid":false,"given":"Kazuo","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saitama Medical University, International Medical Center Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9989-8708","authenticated-orcid":false,"given":"Ritsushi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saitama Medical University, International Medical Center Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,11]]},"reference":[{"key":"e_1_2_23_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.13082"},{"key":"e_1_2_23_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12981"},{"key":"e_1_2_23_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.05.012"},{"key":"e_1_2_23_5_1","article-title":"Pulmonary Vein Narrowing After Pulsed Field Versus Thermal Ablation","volume":"26","author":"Mansour M.","year":"2024","journal-title":"Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, 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Cryoballoon for Atrial Fibrillation Ablation: A Systematic Review and Meta\u2010Analysis","volume":"26","author":"Vetta G.","year":"2024","journal-title":"Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology"},{"key":"e_1_2_23_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-023-02765-x"},{"key":"e_1_2_23_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2023.12.008"},{"key":"e_1_2_23_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2025.01.021"},{"key":"e_1_2_23_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2024.05.001"},{"key":"e_1_2_23_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.04.046"},{"key":"e_1_2_23_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16664"},{"key":"e_1_2_23_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.063988"},{"key":"e_1_2_23_24_1","first-page":"388","article-title":"Comparison of Hemolysis With Different Pulsed Field Ablation Systems","volume":"2025","author":"Kawamura I.","journal-title":"Heart rhythm: the official journal of the Heart Rhythm Society"},{"key":"e_1_2_23_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.124.012732"},{"key":"e_1_2_23_26_1","article-title":"Respiratory Control Minimizes Diaphragmatic Contraction and Dry Cough During Pulsed\u2010Field Ablation of Atrial Fibrillation","volume":"26","author":"Jiang R.","year":"2023","journal-title":"Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology"},{"key":"e_1_2_23_27_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biophys-052118-115451"},{"key":"e_1_2_23_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.124.012765"},{"key":"e_1_2_23_29_1","article-title":"Severe Acute Kidney Injury Related to Haemolysis After Pulsed Field Ablation for Atrial Fibrillation","volume":"26","author":"Venier S.","year":"2023","journal-title":"Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology"},{"key":"e_1_2_23_30_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.106.094235"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70343","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.70343","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:42:12Z","timestamp":1781588532000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.70343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,11]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/jce.70343"],"URL":"https:\/\/doi.org\/10.1111\/jce.70343","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.175740505.59423891\/v1","asserted-by":"object"}]},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,11]]},"assertion":[{"value":"2025-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}