{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:54:36Z","timestamp":1781589276945,"version":"3.54.5"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Cardiac dysfunction secondary to manifest ventricular pre\u2010excitation via accessory pathways (AP) in the absence of tachyarrhythmias is rarely studied. To evaluate pathophysiology, AP location impact, diagnostic approach, and role of catheter ablation (CA) in pre\u2010excitation\u2013related cardiac dysfunction without tachyarrhythmias. Electronic databases were queried for WPW\/pre\u2010excitation and cardiac dysfunction\u2013related studies without age restrictions. A total of 34 studies met inclusion criteria, including 27 case reports\/series (42 patients, 62% female) and 7 observational studies (412 participants, 41% female). Pediatric patients age ranged from infancy to 21 years and adults from 20 to 59 years. Right septal and right free\u2010wall APs were most commonly associated with cardiomyopathy. Heart failure predominated in pediatric presentations, whereas adults most often exhibited asymptomatic LV dysfunction. Intra\u2010LV dyssynchrony, particularly when accompanied by septal dyskinesia, emerged as a consistent pathophysiologic feature. Two\u2010dimensional strain echocardiography (2D\u2010STE) reliably identified LV dysfunction, localized AP, and assessed response to CA. Although cardiac function mostly normalized after successful AP ablation, irreversible myocardial changes have been reported. Preexcitation\u2010related cardiac dysfunction in the absence of tachyarrhythmias, appears to be mediated primarily by intra\u2010LV dyssynchrony and is most commonly associated with right\u2010sided and septal APs. 2D\u2010strain imaging is a useful diagnostic tool. CA typically restores cardiac function, however, irreversible myocardial changes can occur. Therefore, close surveillance and consideration of early ablation in patients with evidence of dyssynchrony are warranted. Large prospective cohort studies can further validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70350","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T07:52:49Z","timestamp":1777276369000},"page":"1326-1339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Manifest Preexcitation\u2010Related Cardiac Dysfunction in the Absence of Tachyarrhythmia: A Systematic Review of Literature"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1270-5863","authenticated-orcid":false,"given":"Mansoor","family":"Rahman","sequence":"first","affiliation":[{"name":"Hamilton Medical Center Dalton Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaid","family":"Abuimweis","sequence":"additional","affiliation":[{"name":"Philadelphia College of Osteopathic Medicine Suwanee Georgia 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