{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:03:01Z","timestamp":1785423781394,"version":"3.56.0"},"reference-count":59,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Left bundle branch area pacing (LBBAP) has been reported to improve long\u2010term clinical outcomes in patients requiring permanent pacemaker implantation (PPMI) after transcatheter aortic valve replacement (TAVR). Deep septal pacing (DSP) has emerged as a potential alternative to LBBAP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated whether short\u2010term and long\u2010term clinical outcomes differ between LBBAP and DSP in post\u2010TAVR patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients undergoing LBBAP or DSP following TAVR were retrospectively included at our institution. Short\u2010term clinical outcomes (1\u2010year follow\u2010up) were assessed by echocardiographic measures of reverse remodeling and changes in QRS duration and N\u2010terminal pro\u2013B\u2010type natriuretic peptide (NT\u2010proBNP) levels. For long\u2010term outcomes, the primary composite endpoint was all\u2010cause mortality or heart failure hospitalization (HFH). Secondary endpoints included HFH and improvement in New York Heart Association (NYHA) class (\u2265\u20092 grades).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 82 patients (39 LBBAP and 43 DSP) were observed for a mean duration of 731.8 days. There was no significant difference between two groups in the risk of primary endpoint (23.1% vs. 23.3%, adjusted hazard ratio [aHR] 0.61; 95% CI: 0.23\u20131.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.315) and HFH (17.9% vs. 20.9%, aHR 0.64; 95% CI: 0.22\u20131.82;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.402). However, LBBAP was a robust predictor of NYHA class improvement compared to DSP (53.8% vs. 27.9%, aHR 2.23; 95% CI: 1.03\u20134.87,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043), especially when left bundle branch (LBB) capture was independently confirmed (aHR 2.74,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). Both modalities were similarly effective in improving electromechanical and biochemical parameters, including LVEF, LVEDD, QRS duration, and NT\u2010proBNP (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LBBAP and DSP yield comparable risks for the primary composite endpoint and HFH, yet LBBAP provides superior symptomatic relief. Confirmation of left bundle branch capture is advisable to optimize clinical benefits.<\/jats:p>\n                    <jats:p>Liangzhen Qu and Xueting Duan contributed equally to this manuscript.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70361","type":"journal-article","created":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T21:05:12Z","timestamp":1777842312000},"page":"1421-1431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Left Bundle Branch Area Pacing versus Deep Septal Pacing in Patients After Transcatheter Aortic Valve Replacement"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2619-8707","authenticated-orcid":false,"given":"Liangzhen","family":"Qu","sequence":"first","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Transvascular Implantation Devices, The Second Affiliated Hospital Zhejiang University School of Medicine 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