{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:02:06Z","timestamp":1785423726756,"version":"3.56.0"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Gain\u2010of\u2010function variants in SCN5A may cause multifocal ectopic Purkinje\u2010related premature contractions (MEPPC), with a high premature ventricular contraction burden that may lead to PVC\u2010induced cardiomyopathy. Pharmacological therapy is usually required, as catheter ablation is ineffective because of the multifocal origin of the ectopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>We report two siblings with the pathogenic SCN5A p.Arg222Gln variant. In both, ranolazine markedly suppressed ventricular ectopy, improved or preserved left ventricular function, and enabled amiodarone withdrawal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ranolazine may represent a useful mechanism\u2010guided option for SCN5A\u2010related MEPPC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70371","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:40:51Z","timestamp":1779302451000},"page":"1618-1622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Use of Ranolazine in SCN5A p.R222Q\u2013Related Multifocal Ectopic Purkinje\u2010Related Premature Contractions"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8450-4246","authenticated-orcid":false,"given":"Isabella Moreira Gonzalez","family":"Fonseca","sequence":"first","affiliation":[{"name":"Hospital das Cl\u00ednicas Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5363-1681","authenticated-orcid":false,"given":"Anna Terra","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Assis Lopes do","family":"Carmo","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8619-1511","authenticated-orcid":false,"given":"Saskia N.","family":"van der Crabben","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Amsterdam University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"van der Werf","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam UMC, Location University of Amsterdam Amsterdam The Netherlands"},{"name":"Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur A. M.","family":"Wilde","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amsterdam UMC, Location University of Amsterdam Amsterdam The Netherlands"},{"name":"Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"569","volume-title":"JACC: Clinical Electrophysiology","author":"Wilde A. A. 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