{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:01:21Z","timestamp":1785423681065,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570391"],"award-info":[{"award-number":["82570391"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","award":["EP\u20102025\u2010000723"],"award-info":[{"award-number":["EP\u20102025\u2010000723"]}],"id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Substrate mapping for atrial fibrillation (AF) ablation commonly relies on sinus rhythm (SR) maps, which may overlook rate\u2010dependent electrophysiological changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the diagnostic and prognostic value of rate\u2010dependent substrate characterization using high\u2010density omnipolar mapping under rapid pacing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a prospective cohort of 46 patients (5 controls, 22 paroxysmal AF [PAF], 19 persistent AF [PeAF]), bi\u2010atrial conduction velocity (CV) and low\u2010voltage zones (LVZ) were assessed across seven mapping conditions: SR and graded pacing (600, 400, 300\u2009ms) from the distal coronary sinus (CSD) and high right atrium (HRA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CV decreased with faster pacing across all cohorts. At 300\u2009ms, PeAF patients exhibited significantly slower CV than PAF and controls (0.60\u2009\u00b1\u20090.07 vs. 0.72\u2009\u00b1\u20090.06 vs. 0.90\u2009\u00b1\u20090.05\u2009m\/s;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The global LVZ burden was greater in PeAF than PAF at 300\u2009ms (58.71 [39.84\u201368.69] vs. 26.18 [20.94\u201337.40];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). Decremental pacing was associated with progressive bi\u2010atrial conduction slowing in AF, most pronounced in PeAF (0.76\u2009\u00b1\u20090.08 vs. 0.74\u2009\u00b1\u20090.06 vs. 0.69\u2009\u00b1\u20090.02 vs. 0.60\u2009\u00b1\u20090.07\u2009m\/s;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Rapid pacing at 300\u2009ms showed the numerically highest discriminative capacity. Patients with global CV\u2009&lt;\u20090.67\u2009m\/s (AUC 0.749;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019) or LVZ% &gt;\u200943.4% (AUC 0.681;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) at 300\u2009ms were associated with a higher risk of recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Rapid pacing at 300\u2009ms reveals latent bi\u2010atrial substrate occult during SR and may improve risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70372","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:04:48Z","timestamp":1778850288000},"page":"1482-1495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Substrate Unmasking via High\u2010Density Omnipolar Mapping Under Rapid Pacing in Atrial Fibrillation"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4314-3525","authenticated-orcid":false,"given":"Xinmeng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tongliao People's Hospital Tongliao Inner Mongolia 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