{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:02:58Z","timestamp":1785423778455,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The optimal number of pulsed field ablation (PFA) applications during atrial fibrillation (AF) ablation is unclear. We hypothesized that the number of PFA applications would predict atrial tachyarrhythmia (ATA) recurrence rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether higher numbers of PFA applications would decrease ATA recurrence rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied cases of patients with AF undergoing first\u2010time ablation with PFA between 5\/6\/24 and 10\/7\/24. All patients underwent pulmonary vein and posterior wall isolation. The primary outcome was ATA recurrence. Additional outcomes included stroke, post\u2010procedural acute kidney injury (AKI), total procedure time, and major periprocedural complications. Univariable and multivariable analyses were performed to determine if the number of PFA applications predicted ATA recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In a cohort consisting of 177 patients, univariable and multivariable analysis showed that the number of PFA applications split at the smallest quartile (&lt;\u200957 applications) versus the largest three quartiles (\u2265\u200957 applications) was the strongest predictor of ATA recurrence (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). ATA recurrence at 1 year (29% vs. 8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and AF burden on continuous monitor (4% vs. 0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) was higher with the standard (&lt;\u200957 applications) vs higher (\u2265\u200957 applications) PFA dose groups. When comparing the standard versus higher PFA dose groups, there was no difference in total procedure time (106 vs. 107\u2009min;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.77), major periprocedural complications (0% vs. 2%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.33), or post\u2010procedural AKI (2% vs. 2%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.69).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Increasing number of PFA applications is associated with reduced ATA recurrence. A higher number of PFA applications may decrease ATA recurrence without affecting procedure times or complication rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70381","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T14:33:26Z","timestamp":1779806006000},"page":"1533-1540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Utility of Higher Pulsed Field Ablation Applications for Atrial Fibrillation Ablation"],"prefix":"10.1111","volume":"37","author":[{"given":"Joey","family":"Junarta","sequence":"first","affiliation":[{"name":"Leon H. Charney Division of Cardiology NYU Langone Health New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine NYU Langone Health New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-5453","authenticated-orcid":false,"given":"Angela","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine NYU Langone Health New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristides","family":"Hatzimemos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine NYU Langone Health New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4190-4909","authenticated-orcid":false,"given":"Pooja","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine NYU Langone Health New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Shields","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine NYU Langone Health New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Yang","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology NYU Langone Health New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirag R.","family":"Barbhaiya","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology NYU Langone Health New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Jankelson","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology NYU Langone Health New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Holmes","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology NYU Langone Health New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kushnir","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology NYU Langone Health New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Garber","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology NYU Langone Health New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology NYU Langone Health New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Park","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology NYU Langone Health New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4454-6761","authenticated-orcid":false,"given":"Larry A.","family":"Chinitz","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology NYU Langone Health New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Aizer","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology NYU Langone Health New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac191"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2021.02.014"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2025.03.515"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307291"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01204.x"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.063988"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.021"},{"issue":"8","key":"e_1_2_14_10_1","first-page":"1","article-title":"Repeat Procedures After Pulsed Field Ablation for Atrial Fibrillation: MANIFEST\u2010REDO Study","volume":"27","author":"Scherr D.","year":"2025","journal-title":"Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2023.11.026"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2025.06.037"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.123.011914"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.1064168"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2025.02.026"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.11.031"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03114-3"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2025.07.026"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.124.012732"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70381","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.70381","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:06:19Z","timestamp":1785420379000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.70381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/jce.70381"],"URL":"https:\/\/doi.org\/10.1111\/jce.70381","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]},"assertion":[{"value":"2026-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}