{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:02:14Z","timestamp":1785423734683,"version":"3.56.0"},"reference-count":59,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The optimal timing of catheter ablation for ventricular tachycardia (VT) in ischemic cardiomyopathy remains uncertain, with strategies ranging from prophylactic intervention to delayed treatment after recurrent arrhythmia. Increasing evidence suggests that the timing of ablation may critically influence both arrhythmic and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To synthesize contemporary evidence on VT ablation timing and to examine the mechanistic and clinical rationale supporting a timing\u2010oriented therapeutic framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a structured narrative review of randomized trials, observational studies, and mechanistic investigations evaluating different ablation strategies, including prophylactic, early, and ICD\u2010guided approaches. Particular emphasis was placed on integrating clinical outcomes with experimental and imaging data on post\u2010infarct substrate evolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Prophylactic ablation reduces arrhythmic burden but has not demonstrated consistent survival benefit. Early ablation strategies improve procedural outcomes but are limited by heterogeneous definitions and inconsistent prognostic impact. By contrast, a timely ICD\u2010guided approach\u2014based on the first device\u2010verified arrhythmic event\u2014has demonstrated consistent reductions in VT recurrence and ICD therapies, with emerging but heterogeneous signals of survival benefit in randomized trials. Mechanistic evidence supports this paradigm, showing that the post\u2010infarct scar is dynamic and continues to remodel over time, with increasing arrhythmogenic complexity. The first ICD\u2010treated arrhythmia may therefore represent a biologically meaningful inflection point for intervention. Imaging and computational tools can refine patient selection and procedural planning after this trigger, while emerging ablation technologies may expand treatment options but do not modify timing strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A timing\u2010oriented approach to VT ablation, anchored to clinically meaningful ICD\u2010verified arrhythmic events, provides the most coherent integration of mechanistic insight and clinical evidence. This strategy may also have relevant implications for healthcare utilization, although formal cost\u2010effectiveness data remain limited. Future work should focus on refining patient selection within this therapeutic window and evaluating how evolving technologies can be integrated without compromising the central importance of timing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70390","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:00:23Z","timestamp":1780398023000},"page":"1577-1587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Timing of Catheter Ablation for Ventricular Tachycardia in Ischemic Cardiomyopathy: Evidence, Mechanisms, and the Emerging Role of Timely ICD\u2010Guided Intervention"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6975-3850","authenticated-orcid":false,"given":"Federico","family":"Turreni","sequence":"first","affiliation":[{"name":"Cardiology Division Santa Maria della Stella Hospital Orvieto Italy"},{"name":"Cardiology Unit Sandro Pertini Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9048-2039","authenticated-orcid":false,"given":"Luca","family":"Santini","sequence":"additional","affiliation":[{"name":"Cardiology Unit G.B. Grassi Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Loricchio","sequence":"additional","affiliation":[{"name":"Cardiology Unit Sandro Pertini Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Castro","sequence":"additional","affiliation":[{"name":"Cardiology Unit Sandro Pertini Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaello Molino","family":"Lova","sequence":"additional","affiliation":[{"name":"Private Practice Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio Garcia","family":"Bolao","sequence":"additional","affiliation":[{"name":"Clinica Universidad de Navarra University of Navarra Pamplona Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Solimene","sequence":"additional","affiliation":[{"name":"Montevergine Clinic Mercogliano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Granatelli","sequence":"additional","affiliation":[{"name":"Cardiology Unit Sandro Pertini Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Giaccardi","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties, Azienda USL Toscana Centro Unit of Interventional Cardiology Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Colella","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Chechi","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties, Azienda USL Toscana Centro Unit of Interventional Cardiology Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0615-9525","authenticated-orcid":false,"given":"Riccardo","family":"Cappato","sequence":"additional","affiliation":[{"name":"Arrhythmia and Clinical Electrophysiology Center IRCCS MultiMedica, Sesto San Giovann Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065457"},{"key":"e_1_2_7_3_1","first-page":"274","article-title":"Catheter Ablation of Stable Ventricular Tachycardia before Defibrillator Implantation in Patients With Coronary Heart Disease (VTACH)","volume":"121","author":"Kuck K. 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