{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:34:40Z","timestamp":1786714480641,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>VT ablation reduces arrhythmic burden and ICD therapies, yet VT recurrence remains common. A key limitation is incomplete identification and durable elimination of the slow\u2010conduction substrate. Structural imaging and ECGi provide complementary information but are not routinely integrated into a workflow\u2010ready ablation strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>APOLO\u2010VT aims to evaluate the feasibility, safety, and clinical impact of an integrated multimodal mapping workflow combining noninvasive structural and functional substrate characterization using ECGi with invasive EAM to support VT ablation targeting and verification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>APOLO\u2010VT is an interventional, prospective, single\u2010center investigation enrolling 60 adults with structural heart disease undergoing VT ablation. Scar\/border\u2010zone characterization will be derived from LGE\u2010CMR (or CT when contraindicated) and integrated with ECGi maps and invasive EAM. Noninvasively defined targets will be ablated, followed by S3\u2010paced ECGi remapping; persistent deceleration zones will prompt additional ablation. If the S3\u2010paced ECGi map is free of deceleration zones, programmed stimulation and an invasive S3\u2010paced map will be performed to confirm endpoint achievement. Follow\u2010up will be 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The primary endpoint is VT recurrence at 12 months. Secondary endpoints include acute non\u2010inducibility, procedural efficiency, safety outcomes, mortality, and mechanistic concordance analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>APOLO\u2010VT will provide prospective feasibility, safety, mechanistic, and exploratory outcome data on a standardized noninvasive\u2010to\u2010invasive multimodal strategy with iterative post\u2010ablation functional noninvasive reassessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70410","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:56:01Z","timestamp":1782413761000},"page":"1801-1807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Digital Twin Guided Ventricular Tachycardia Ablation: Design and Rationale of the APOLO\u2010VT Trial"],"prefix":"10.1111","volume":"37","author":[{"given":"Pranav","family":"Bhagirath","sequence":"first","affiliation":[{"name":"Institut Cl\u00ednic Cardiovascular, Hospital Cl\u00ednic Universitat de Barcelona Barcelona Spain"},{"name":"School of Biomedical Engineering and Imaging Sciences King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariona","family":"Regany","sequence":"additional","affiliation":[{"name":"Institut Cl\u00ednic Cardiovascular, Hospital Cl\u00ednic Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Borr\u00e0s","sequence":"additional","affiliation":[{"name":"Institut Cl\u00ednic Cardiovascular, Hospital Cl\u00ednic Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-5319","authenticated-orcid":false,"given":"Eduard","family":"Guasch","sequence":"additional","affiliation":[{"name":"Institut Cl\u00ednic Cardiovascular, Hospital Cl\u00ednic Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Llu\u00eds","family":"Mont","sequence":"additional","affiliation":[{"name":"Institut Cl\u00ednic Cardiovascular, Hospital Cl\u00ednic Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Tolosana","sequence":"additional","affiliation":[{"name":"Institut Cl\u00ednic Cardiovascular, Hospital Cl\u00ednic Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3510-1488","authenticated-orcid":false,"given":"Andreu","family":"Porta\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Institut Cl\u00ednic Cardiovascular, Hospital Cl\u00ednic Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Roca\u2010Luque","sequence":"additional","affiliation":[{"name":"Institut Cl\u00ednic Cardiovascular, Hospital Cl\u00ednic Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The APOLO Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac262"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.01.050"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.060039"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513614"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2025.02.034"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz132"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.07.043"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2025.09.028"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2025.07.020"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-025-01332-5"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa021"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2024.04.023"}],"container-title":["Journal 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