{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:34:41Z","timestamp":1786714481398,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Frequent PVCs have been associated with a reversible cardiomyopathy. Cutoffs of \u2265\u200910\u2009000 PVCs\/day and \u2265\u200915% PVCs have been suggested by the 2014 EHRA\/HRS\/APHRS and 2017 AHA\/ACC\/HRS Expert Consensus guidelines, respectively, for PVC suppression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the impact of PVC variability on meeting guideline\u2010suggested PVC thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Six hundred and six patients with 14\u2010day ZIO monitor data sets with \u2265\u200910\u2009000 PVCs on at least 1 day were identified (2014 guidelines cohort). Of these patients, 325 had at least 1 day of \u2265\u200915% PVCs (2017 guidelines cohort). Analysis was performed on these cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Within the 2014 guidelines cohort, mean daily PVC burden was 12\u2009188\u2009\u00b1\u20098300 [range 0\u201364\u2009188]. Intra\u2010patient daily PVCs were highly variable (median 3.6\u2010fold change between max and min PVC days (Q1\/3: 2.22\/10.15) with instances of &gt;\u200910\u2009000\u2010fold change observed. 54.3% and 19.5% of patients had days with &lt;\u20095000 and &lt;\u20091000 PVCs, respectively. Even patients with days of 0 PVCs (0.5%) were observed. Seventy\u2010two hours of monitoring detected 69% of patients with \u2265\u200910\u2009000 PVCs\/24\u2009h with an additional 2%\u20134% of patients crossing the threshold each additional day. A bimodal distribution of the number of days meeting PVC thresholds\/corresponding PVC counts was observed, suggesting a previously unidentified pattern of distinct populations\u2014\u201clow frequency\/low PVC\u201d (\u2264\u20093\/14 above\u2010threshold days\/mean 12\u2009342 PVCs those days) versus \u201chigh frequency\/high PVC\u201d (14\/14 above\u2010threshold days\/mean 24\u2009580 PVCs those days). The 2017 guidelines cohort demonstrated similar findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Daily PVC burdens vary greatly. More sensitive detection of guideline\u2010suggested cut\u2010offs requires prolonged monitoring. Novel potential PVC patterns may allow for better identification of candidates for PVC suppression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70416","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:57:27Z","timestamp":1782413847000},"page":"1817-1827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PVC Variability and Impact on Meeting Expert Consensus Cutoffs of \u2265\u200910\u2009000 PVCs\/Day and \u2265\u200915% PVCs"],"prefix":"10.1111","volume":"37","author":[{"given":"Richard S.","family":"Amara","sequence":"first","affiliation":[{"name":"Division of Cardiology University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Brilliant","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Appelbaum","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameer","family":"Abutaleb","sequence":"additional","affiliation":[{"name":"George Washington Transplant Institute Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9431-7997","authenticated-orcid":false,"given":"Rama","family":"Vunnam","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Shorofsky","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey N.","family":"Rottman","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardit","family":"Kacorri","sequence":"additional","affiliation":[{"name":"iRhythm Technologies Inc. San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timm M.","family":"Dickfeld","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)63724-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.546432"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.08.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.03.036"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000805"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.03.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2015.04.005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.07.024"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.054"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12852"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.04.033"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.07.013"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.04.066"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.11.016"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70416","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.70416","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:57:33Z","timestamp":1786712253000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.70416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/jce.70416"],"URL":"https:\/\/doi.org\/10.1111\/jce.70416","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"assertion":[{"value":"2026-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}