{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:42:17Z","timestamp":1789486937602,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Use of high\u2010frequency low\u2010tidal volume (HFLTV) and high\u2010frequency jet ventilation (HFJV) during pulmonary vein isolation (PVI) improves acute procedural success and long\u2010term outcomes compared to conventional ventilation. However, the impact of HFLTV compared to HFJV on acute and long\u2010term outcomes is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively identified 1039 patients who underwent first\u2010time PVI or PVI with posterior wall isolation (PWI) at our institution between 2022 and 2024 with HFLTV or HFJV. Acute procedural and safety outcomes were analyzed. Twelve\u2010month arrhythmia\u2010free survival was evaluated using the Kaplan\u2010Meier and Cox proportional hazards method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After excluding 44 patients who required discontinuation of HFJV, 860 patients receiving HFJV were compared with 179 receiving HFLTV ventilation. Mean age was 65 years, 93% were White, 30% female and 53% had paroxysmal AF. First\u2010pass isolation (FPI) rates were similar between ventilation strategies. HFLTV was associated with a higher rate of intraprocedural hypotension (31% vs 23%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Complications were generally minor and comparable between groups. Arrhythmia recurrence rates at 12 months were similar (HR: 0.89,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.55). There was a trend toward improved outcomes when FPI was achieved for both pulmonary veins in either group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this observational cohort, no significant differences in acute procedural outcomes, safety outcomes, or long\u2010term arrhythmia recurrence were observed between HFLTV and HFJV. Given the specialized equipment and operator training required for HFJV and its non\u2010negligible rate of discontinuation, HFLTV may offer a modest practical advantage in routine clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70422","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:05:01Z","timestamp":1782857101000},"page":"1921-1929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of High\u2010Frequency Low\u2010Tidal Volume Versus Jet Ventilation on Acute and Long\u2010Term Outcomes Following Pulmonary Vein Isolation"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9719-4870","authenticated-orcid":false,"given":"Daniel","family":"Villarreal","sequence":"first","affiliation":[{"name":"Harvard\u2010Thorndike Arrhythmia Institute, Beth Israel Deaconess Medical Center Division of Cardiovascular Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Perez\u2010Pinzon","sequence":"additional","affiliation":[{"name":"Department of Medicine Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"d'Avila","sequence":"additional","affiliation":[{"name":"Harvard\u2010Thorndike Arrhythmia Institute, Beth Israel Deaconess Medical Center Division of Cardiovascular Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Zimetbaum","sequence":"additional","affiliation":[{"name":"Harvard\u2010Thorndike Arrhythmia Institute, Beth Israel Deaconess Medical Center Division of Cardiovascular Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H.","family":"Locke","sequence":"additional","affiliation":[{"name":"Harvard\u2010Thorndike Arrhythmia Institute, Beth Israel Deaconess Medical Center Division of Cardiovascular Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Yang","sequence":"additional","affiliation":[{"name":"Harvard\u2010Thorndike Arrhythmia Institute, Beth Israel Deaconess Medical Center Division of Cardiovascular Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Maher","sequence":"additional","affiliation":[{"name":"Harvard\u2010Thorndike Arrhythmia Institute, Beth Israel Deaconess Medical Center Division of Cardiovascular Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sankalp","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Boston Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian S.","family":"Schaeffer","sequence":"additional","affiliation":[{"name":"Department of Anesthesia &amp; Critical Care, Harvard Medical School Beth Israel Deaconess Medical Center Boston Massachusetts USA"},{"name":"Center for Anesthesia Research Excellence (CARE) Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian D.","family":"Sahli","sequence":"additional","affiliation":[{"name":"Department of Anesthesia &amp; Critical Care, Harvard Medical School Beth Israel Deaconess Medical Center Boston Massachusetts USA"},{"name":"Center for Anesthesia Research Excellence (CARE) Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Waks","sequence":"additional","affiliation":[{"name":"Harvard\u2010Thorndike Arrhythmia Institute, Beth Israel Deaconess Medical Center Division of Cardiovascular Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Tung","sequence":"additional","affiliation":[{"name":"Harvard\u2010Thorndike Arrhythmia Institute, Beth Israel Deaconess Medical Center Division of Cardiovascular Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.042622"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2024.05.004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12950"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2018.08.016"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-022-01123-1"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.06.011"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2023.111324"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2023.05.015"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.07.094"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCRC.2020.11.002"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BJA.2019.01.013"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005739"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16190"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13020186"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14507"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.03.418"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2021.05.005"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.JVCA.2011.11.011"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.4022\/JAFIB.20200641"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70422","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.70422","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:38:59Z","timestamp":1789479539000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.70422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/jce.70422"],"URL":"https:\/\/doi.org\/10.1111\/jce.70422","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"assertion":[{"value":"2025-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}