{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:50:14Z","timestamp":1791949814026,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370355"],"award-info":[{"award-number":["82370355"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inadvertent left atrial appendage electrical isolation (LAAEI) during persistent atrial fibrillation (AF) ablation increases thromboembolic risk. The optimal antithrombotic strategy for these patients remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to compare the safety and efficacy of left atrial appendage closure (LAAC) performed within 3 months after catheter ablation versus long\u2010term postoperative received direct oral anticoagulants (DOACs) in patients with persistent AF who experienced inadvertent LAAEI during catheter ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The single\u2010center retrospective analysis included 225 patients with inadvertent LAAEI during persistent AF ablation between January 2019 and March 2024. After propensity score matching (PSM), 144 patients were analyzed: 72 received LAAC (LAAC group), and 72 received DOACs (DOAC group). Outcomes, including bleeding and thromboembolic events, were assessed over a mean follow\u2010up of 827 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The LAAC group had significantly fewer non\u2010procedure\u2010related major and clinically relevant nonmajor bleeding events compared to the DOAC group (HR\u2009=\u20090.417, 95% CI: 0.181\u20130.960,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034). Thromboembolic events were similar (HR\u2009=\u20090.246, 95% CI: 0.071\u20130.851,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.205). Atrial arrhythmia recurrence rates were comparable (HR\u2009=\u20090.939, 95% CI: 0.587\u20131.502,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.054). Normal LAA function was observed in 41.67% of the DOAC group, while the LAAC group had two cases of device\u2010related thrombus resolved with anticoagulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LAAC within 3 months after catheter ablation may reduce bleeding risk while maintaining efficacy comparable to long\u2010term DOACs in patients with inadvertent LAAEI. LAAC represents a safe and effective strategy for this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70423","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:20:32Z","timestamp":1784226032000},"page":"2212-2221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of Different Stroke Prevention Strategies in Patients With Inadvertent Left Atrial Appendage Electrical Isolation"],"prefix":"10.1111","volume":"37","author":[{"given":"Shaohui","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiongchao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3773-1424","authenticated-orcid":false,"given":"Shiyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8301-2826","authenticated-orcid":false,"given":"Zhuangzhuang","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Third Affiliated Hospital of Anhui Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bosheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.07.770"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.10.036"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15889"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.06.045"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/circep.120.008390"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz161"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-019-00603-1"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.09.831"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2408308"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.118.037451"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.11.009"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa174"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac167"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa266"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2024.11.018"}],"container-title":["Journal 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