{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T19:14:04Z","timestamp":1788117244865,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In patients with ischemic cardiomyopathy (ICM), recurrent VF may be treated with catheter ablation by targeting triggering premature ventricular complexes (PVCs) and\/or ventricular scar homogenization. Data on optimal ablation strategies in patients with non\u2010ischemic cardiomyopathy (NICM) remain limited. This study aimed to compare ablation strategies and outcomes in patients with recurrent VF due to ICM versus NICM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed consecutive patients with structural heart disease and recurrent VF undergoing catheter ablation. Catheter ablation was performed, including targeting the triggering and\/or clinically frequent PVC, targeting any inducible ventricular tachycardia, and\/or scar homogenization. Procedural characteristics, arrhythmogenic substrate features, and post\u2010ablation clinical outcomes were compared between ICM and NICM groups. Forty\u2010five patients were included (17 ICM, 28 NICM; mean age 60\u2009\u00b1\u200915 years; 87% male). PVC ablation was performed in 42% of ICM and 39% of NICM patients, while scar homogenization was undertaken in 76% and 57%, respectively. Left ventricular scar burden, assessed by bipolar and unipolar voltage mapping, was significantly greater in the ICM, whereas the prevalence of abnormal Purkinje potentials was similar between groups. VF\u2010free survival after multiple procedures did not differ between groups, with estimated 1\u2010year rates of 87\u2009\u00b1\u20099% in ICM and 85\u2009\u00b1\u20098% in NICM (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.93).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with NICM and recurrent VF, catheter ablation targeting arrhythmogenic substrate\u2014including unipolar low\u2010voltage regions\u2014combined with PVC ablation yields outcomes comparable to those in ICM, supporting this approach as a reasonable treatment strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70488","type":"journal-article","created":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T18:24:27Z","timestamp":1788114267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes After Catheter Ablation in Patients With Structural Heart Disease and Ventricular Fibrillation"],"prefix":"10.1111","author":[{"given":"Kenji","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Department of Cardiology, Westmead Hospital, Westmead Applied Research Centre University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samual","family":"Turnbull","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Westmead Hospital, Westmead Applied Research Centre University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Westmead Hospital, Westmead Applied Research Centre University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,30]]},"reference":[{"issue":"26","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1056\/NEJMoa065457","article-title":"Prophylactic Catheter Ablation for the Prevention of Defibrillator Therapy","volume":"357","author":"Reddy V. Y.","year":"2007","journal-title":"New England Journal of Medicine"},{"issue":"3","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrcardio.2015.193","article-title":"Ventricular Arrhythmias and the His\u2010Purkinje System","volume":"13","author":"Haissaguerre M.","year":"2016","journal-title":"Nature Reviews Cardiology"},{"issue":"5","key":"e_1_2_10_4_1","article-title":"Electrical Substrate Elimination in 135 Consecutive Patients With Brugada Syndrome","volume":"10","author":"Pappone C.","year":"2017","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"issue":"20","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1161\/CIRCULATIONAHA.118.037997","article-title":"Catheter Ablation of Refractory Ventricular Fibrillation Storm After Myocardial Infarction","volume":"139","author":"Komatsu Y.","year":"2019","journal-title":"Circulation"},{"issue":"12","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.hrcr.2020.10.002","article-title":"Termination of Long\u2010Duration Ventricular Fibrillation by Catheter Ablation","volume":"6","author":"Hasegawa T.","year":"2020","journal-title":"HeartRhythm Case Reports"},{"issue":"12","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1093\/eurheartj\/ehab893","article-title":"Purkinje Network and Myocardial Substrate at the Onset of Human Ventricular Fibrillation: Implications for Catheter Ablation","volume":"43","author":"Haissaguerre M.","year":"2022","journal-title":"European Heart Journal"},{"issue":"8","key":"e_1_2_10_8_1","first-page":"1781","article-title":"Fascicular Substrate Modification to Treat Human Ventricular Fibrillation","volume":"10","author":"Bode W. D.","year":"2024","journal-title":"JACC: Clinical Electrophysiology"},{"issue":"12","key":"e_1_2_10_9_1","article-title":"Does Ventricular Tachycardia Ablation Targeting Local Abnormal Ventricular Activity Elimination Reduce Ventricular Fibrillation Incidence?","volume":"12","author":"Kitamura T.","year":"2019","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"issue":"2","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/eurheartj\/ehm342","article-title":"Classification of the Cardiomyopathies: A Position Statement From the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases","volume":"29","author":"Elliott P.","year":"2008","journal-title":"European Heart Journal"},{"issue":"1","key":"e_1_2_10_11_1","first-page":"49","article-title":"Endocardial Unipolar Voltage Mapping to Detect Epicardial Ventricular Tachycardia Substrate in Patients With Nonischemic Left Ventricular Cardiomyopathy","volume":"4","author":"Hutchinson M. D.","year":"2011","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"issue":"11","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1161\/01.CIR.101.11.1288","article-title":"Linear Ablation Lesions for Control of Unmappable Ventricular Tachycardia in Patients With Ischemic and Nonischemic Cardiomyopathy","volume":"101","author":"Marchlinski F. E.","year":"2000","journal-title":"Circulation"},{"issue":"1","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.hrthm.2010.09.088","article-title":"Endocardial Unipolar Voltage Mapping to Identify Epicardial Substrate in Arrhythmogenic Right Ventricular Cardiomyopathy\/Dysplasia","volume":"8","author":"Polin G. M.","year":"2011","journal-title":"Heart Rhythm: The Official Journal of the Heart Rhythm Society"},{"issue":"1","key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"e220","DOI":"10.1016\/j.hrthm.2019.02.034","article-title":"2019 HRS\/EHRA\/APHRS\/LAHRS Focused Update to 2015 Expert Consensus Statement on Optimal Implantable Cardioverter\u2010Defibrillator Programming and Testing","volume":"17","author":"Stiles M. K.","year":"2020","journal-title":"Heart Rhythm: The Official Journal of the Heart Rhythm Society"},{"issue":"1","key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/jce.12547","article-title":"Mapping and Ablating Ventricular Premature Contractions That Trigger Ventricular Fibrillation: Trigger Elimination and Substrate Modification","volume":"26","author":"Nogami A.","year":"2015","journal-title":"Journal of Cardiovascular Electrophysiology"},{"issue":"7","key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.hrthm.2019.01.032","article-title":"Catheter Ablation of Polymorphic Ventricular Tachycardia\/Fibrillation in Patients With and Without Structural Heart Disease","volume":"16","author":"Nakamura T.","year":"2019","journal-title":"Heart Rhythm: The Official Journal of the Heart Rhythm Society"},{"issue":"3","key":"e_1_2_10_17_1","article-title":"Electrical Substrate Ablation for Refractory Ventricular Fibrillation: Results of the AVATAR Study: Results of the AVATAR Study","volume":"14","author":"Krummen D. E.","year":"2021","journal-title":"Circulation: Arrhythmia and Electrophysiology"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.70488","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.70488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T18:24:29Z","timestamp":1788114269000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.70488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,30]]},"references-count":16,"alternative-id":["10.1111\/jce.70488"],"URL":"https:\/\/doi.org\/10.1111\/jce.70488","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,30]]},"assertion":[{"value":"2026-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jce.70488"}}