{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:05:23Z","timestamp":1789499123604,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pulsed field ablation (PFA) is an emerging non\u2010thermal ablation modality with proven safety in atrial arrhythmia ablation. However, data on its performance for ventricular arrhythmias (VA) remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the feasibility, safety, and efficacy of PFA for complex VA in a multicenter real\u2010world US registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included consecutive patients undergoing PFA for ventricular tachycardia (VT) or premature ventricular contractions (PVCs) at three Mayo Clinic centers (April 2024 to July 2025). The primary feasibility outcome was the successful delivery of PFA lesions to the intended target substrate. Primary efficacy outcomes included acute procedural success; sustained VT recurrence requiring implantable cardioverter\u2010defibrillator (ICD) shocks or multiple antitachycardia pacing therapies; and \u2265\u200980% reduction in PVC burden. Safety outcomes included procedural complications, valvular function, thromboembolic events, renal function, and conduction disturbances.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010six patients were included (13 PVC, 13 VT). Acute success was achieved in all VT ablations (69.2% complete; 30.8% partial) and in 92.3% of PVC ablations. Complications occurred in 11.5% of patients (transient LBBB [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091] and vascular complications [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092]). No thromboembolic events, intracardiac thrombus, or acute kidney injury were observed. Lesions near the mitral valve apparatus did not worsen mitral regurgitation, including in patients with pre\u2010existing valve disease. After a median follow\u2010up of 365 days, one patient experienced VT recurrence requiring ICD shocks. Estimated recurrence\u2010free survival after VT ablation was 61.5% at 12 months; 58.3% of PVC patients achieved \u2265\u200980% burden reduction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PFA for VA appears feasible and acutely effective, with a low rate of procedure\u2010related complications. While acute success was high, long\u2010term outcomes were acceptable for VT ablation and relatively modest for PVC ablation, highlighting the need for continued refinement of technology and energy\u2010delivery strategies. Larger prospective studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70503","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:29:27Z","timestamp":1789496967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility, Safety, and Efficacy of Pulsed Field Ablation for Ventricular Arrhythmias: Insights From a Large Health System Registry in the United States"],"prefix":"10.1111","author":[{"given":"Narut","family":"Prasitlumkum","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8271-9128","authenticated-orcid":false,"given":"Juan F.","family":"Rodriguez\u2010Riascos","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2942-1031","authenticated-orcid":false,"given":"Hema","family":"Vemulapalli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9555-3626","authenticated-orcid":false,"given":"Aakash","family":"Somappa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7242-680X","authenticated-orcid":false,"given":"Camilo A.","family":"Estrada\u2010Vargas","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2869-5022","authenticated-orcid":false,"given":"Olubadewa A.","family":"Fatunde","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Rojas","sequence":"additional","affiliation":[{"name":"Division Chair\u2010Cardiothoracic Radiology Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4959-1344","authenticated-orcid":false,"given":"Poojan","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6384-9525","authenticated-orcid":false,"given":"Keerthika","family":"Vijayakumar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2283-4340","authenticated-orcid":false,"given":"Suraj","family":"Kapa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duy","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9835-5536","authenticated-orcid":false,"given":"Samuel","family":"Asirvatham","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malini","family":"Madhavan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6851-0152","authenticated-orcid":false,"given":"Christopher","family":"McLeod","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2470-2862","authenticated-orcid":false,"given":"Hicham Z. El","family":"Masry","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9560-1102","authenticated-orcid":false,"given":"Abhishek J.","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danesh K.","family":"Kella","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5525-1806","authenticated-orcid":false,"given":"Ammar M.","family":"Killu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7694-3617","authenticated-orcid":false,"given":"Siva K.","family":"Mulpuru","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Sardana","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1010-1062","authenticated-orcid":false,"given":"Luis R.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan M.","family":"Sugrue","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9732-0243","authenticated-orcid":false,"given":"Komandoor","family":"Srivathsan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jacc.2024.05.001","article-title":"Pulsed Field vs Conventional Thermal Ablation for Paroxysmal Atrial Fibrillation","volume":"84","author":"Reddy V. 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D.","year":"2021","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"issue":"10","key":"e_1_2_9_9_1","article-title":"Effect of Pulsed\u2010Field and Radiofrequency Ablation on Heterogeneous Ventricular Scar in a Swine Model of Healed Myocardial Infarction","volume":"15","author":"Younis A.","year":"2022","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"issue":"8","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.hrthm.2024.04.081","article-title":"Pulsed Field Ablation for Incessant Scar\u2010Related Ventricular Tachycardia: First US Report","volume":"21","author":"Katrapati P.","year":"2024","journal-title":"Heart Rhythm: The Official Journal of the Heart Rhythm Society"},{"issue":"8","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"e485","DOI":"10.1016\/j.hrthm.2024.10.067","article-title":"Ablation of Premature Ventricular Complexes Originating From Papillary Muscle Using Pulsed Field Energy: The First in USA Experience","volume":"22","author":"Muthu P.","year":"2025","journal-title":"Heart Rhythm: The Official Journal of the Heart Rhythm Society"},{"issue":"6","key":"e_1_2_9_12_1","first-page":"722","article-title":"Pulsed Field Ablation of Left Ventricular Myocardium in a Swine Infarct Model","volume":"8","author":"Im S. 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