{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:50:18Z","timestamp":1791949818207,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pulsed field ablation (PFA) is an emerging modality for atrial fibrillation (AF) ablation. However, adequate sedation of patients during treatment is imperative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our aim was to compare safety and outcome after deep sedation (DS) managed by electrophysiology staff (EP\u2010DS), DS by an anaesthesia nurse (AN\u2010DS), and general anaesthesia (GA) during PFA AF ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All Danish patients undergoing first\u2010time AF ablation with pentaspline PFA technique from 2021 to 2024 were included. Patients were stratified according to sedation strategy. EP\u2010DS and AN\u2010DS were defined as sedation without assisted ventilation managed by EP staff and an anaesthesia nurse, respectively. Patients in GA underwent endotracheal intubation and were monitored by anaesthesia staff. Patient selection for the sedation strategy was based on the institutional practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1269 patients, 661 (52%) underwent EP\u2010DS, 173 (14%) underwent AN\u2010DS, and 435 (34%) underwent GA. Overall, sedation complications were few, and no procedures were abandoned due to adverse effects of sedation. In the EP\u2010DS group, the anaesthesiologist was unexpectedly called for back\u2010up in 1 (0.2%) patient due to prolonged hypotension during the procedure. In the AN\u2010DS group, the anaesthesiologist was called due to desaturation in 1 patient (0.6%) but without the need for escalation to intubation. In the GA group, no periprocedural sedation complications occurred. We found no difference in 1\u2010year atrial tachycardia recurrence between sedation groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this nationwide cohort, EP staff\u2010administered deep sedation was feasible and associated with few clinically significant sedation\u2010related adverse events during PFA. No significant differences in observed atrial tachyarrhythmia recurrence rates were identified between sedation strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70516","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:04:01Z","timestamp":1790532241000},"page":"2393-2402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Comparison of Safety and Outcome Using Three Different Sedation Strategies During Pulsed Field Ablation for Atrial Fibrillation"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5151-025X","authenticated-orcid":false,"given":"Christina","family":"Alhede","sequence":"first","affiliation":[{"name":"Heart Center Copenhagen Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurits Juhl","family":"Heinsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3760-5122","authenticated-orcid":false,"given":"Mille Ravn","family":"Sandgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Pontoppidan","sequence":"additional","affiliation":[{"name":"Molholm Hospital Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8188-7912","authenticated-orcid":false,"given":"Katrine V\u00e6sel","family":"Wade","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1685-306X","authenticated-orcid":false,"given":"Uffe","family":"Gang","sequence":"additional","affiliation":[{"name":"Heart Center Copenhagen Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen Buus","family":"Kristiansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0294-3750","authenticated-orcid":false,"given":"Arne","family":"Johannessen","sequence":"additional","affiliation":[{"name":"Heart Center Copenhagen Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Osmanagic","sequence":"additional","affiliation":[{"name":"Department of Cardiology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla Lundegaard","family":"Asferg","sequence":"additional","affiliation":[{"name":"Zealand University Hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Steen","family":"Hansen","sequence":"additional","affiliation":[{"name":"Molholm Hospital Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1849-9463","authenticated-orcid":false,"given":"Sam","family":"Riahi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1541-309X","authenticated-orcid":false,"given":"Martin H.","family":"Ruwald","sequence":"additional","affiliation":[{"name":"Heart Center Copenhagen Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1520-8774","authenticated-orcid":false,"given":"Peter Karl","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Heart Center Copenhagen Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2876-7388","authenticated-orcid":false,"given":"Niels C. 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