{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:57:42Z","timestamp":1791295062946,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V113C\u2010069"],"award-info":[{"award-number":["V113C\u2010069"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V114C\u2010062"],"award-info":[{"award-number":["V114C\u2010062"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V115C\u2010005"],"award-info":[{"award-number":["V115C\u2010005"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Contemporary Asian data on 24\u2010month outcomes after cryoballoon ablation (CBA) in predominantly paroxysmal atrial fibrillation (AF) are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter registry across four Taiwanese tertiary centers (2018\u20132023). Consecutive patients undergoing CBA were analyzed for documented atrial\u2010arrhythmia recurrence (\u2265\u200930\u2010s episodes after a 90\u2010day blanking period) and 12\u2010month quality of life (QoL; EQ\u20105D\u20103L index and visual analogue scale [VAS]). Rhythm follow\u2010up relied mainly on intermittent ECG, Holter, event\u2010recorder, or clinically indicated rhythm assessment. Cox models identified recurrence predictors; QoL analyses used paired complete\u2010case data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 298 patients (age 63.7\u2009\u00b1\u200911.8 years, 60% men), 282 (94.6%) had paroxysmal AF. Procedure\u2010related adverse events were rare (2.0%), with no tamponade or atrioesophageal fistula. Fifty\u2010eight patients (19%) had post\u2010blanking documented recurrence (late 90\u2013365 days:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937; very late &gt;\u2009365 days:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921). Kaplan\u2013Meier recurrence\u2010free survival under intermittent monitoring was approximately 90% at 12 months and 62% at 24 months, with wider confidence bands beyond 18 months. In multivariable analysis, longer time from AF diagnosis to ablation independently predicted recurrence (adjusted HR 1.050 per year, 95% CI 1.007\u20131.096;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023); left\u2010ventricular ejection fraction showed a borderline inverse association (adjusted HR 0.970 per 1%, 95% CI 0.942\u20131.000;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.052). QoL analyses in 205\/298 patients with paired data showed no significant change in EQ\u20105D\u20103L index (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.672), but VAS categories shifted toward lower symptom burden (moderate\/high 21.5% to 10.2%). A clinically meaningful VAS improvement (\u2265\u200910 points) occurred in 34% (70\/205). Because paired QoL data were incomplete and the logistic model was unstable owing to sparse events and quasi\u2010complete separation, no robust independent predictor of VAS improvement could be confirmed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this multicenter Taiwanese registry of predominantly paroxysmal AF, CBA had a low complication rate and high 12\u2010month freedom from documented arrhythmia under intermittent monitoring. Longer time from AF diagnosis to ablation was associated with recurrence. Among patients with paired QoL data, one\u2010third achieved clinically meaningful VAS improvement despite an unchanged EQ\u20105D\u20103L index.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.70518","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:14:57Z","timestamp":1791292497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Recurrence and Quality of Life After Cryoballoon Ablation in Atrial Fibrillation: Data From a Multicenter Taiwanese Registry With 24\u2010Month Follow\u2010Up"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4734-6191","authenticated-orcid":false,"given":"Lo\u2010Chieh","family":"Ling","sequence":"first","affiliation":[{"name":"Department of Cardiology, Department of Internal Medicine, Shin Kong Wu Ho\u2010Su Memorial Hospital Taipei Taiwan"},{"name":"Division of Cardiac Electrophysiology, Cardiovascular Center Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang\u2010Ming Chiao Tung University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-0057","authenticated-orcid":false,"given":"Ting\u2010Yung","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiac Electrophysiology, Cardiovascular Center Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang\u2010Ming Chiao Tung University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0363-2065","authenticated-orcid":false,"given":"Cheng\u2010Hung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology Taichung Veterans General Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7030-8471","authenticated-orcid":false,"given":"Shih\u2010Lin","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiac Electrophysiology, Cardiovascular Center Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang\u2010Ming Chiao Tung University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1882-9664","authenticated-orcid":false,"given":"Ying\u2010Hsiang","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine MacKay Memorial Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Hsiung","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine MacKay Memorial Hospital Taipei 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