{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T23:03:49Z","timestamp":1756076629164},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T00:00:00Z","timestamp":1347408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p><jats:italic>J Clin Hypertens (Greenwich)<\/jats:italic>. 2012;14:773\u2013778. \u00a92012 Wiley Periodicals, Inc.<\/jats:p><jats:p>Postmenopausal women are at greater risk for hypertension\u2010related cardiovascular disease. Antihypertensive therapy may help alleviate arterial stiffness that represents a potential modifiable risk factor of hypertension. This randomized controlled study investigated the difference between an angiotensin receptor blocker and a calcium channel blocker in reducing arterial stiffness. Overall, 125 postmenopausal hypertensive women (age, 61.4\u00b16\u2003years; systolic blood pressure\/diastolic blood pressure [SBP\/DBP], 158\u00b111\/92\u00b19\u2003mm\u2003Hg) were randomized to valsartan 320\u2003mg\u00b1hydrochlorothiazide (HCTZ) (n=63) or amlodipine 10\u2003mg\u00b1HCTZ (n=62). The primary outcome was carotid\u2010to\u2010femoral pulse wave velocity (PWV) changes after 38\u2003weeks of treatment. Both treatments lowered peripheral blood pressure (BP) (\u221222.9\/\u221210.9\u2003mm\u2003Hg for valsartan and \u221225.2\/\u221211.7\u2003mm\u2003Hg for amlodipine, <jats:italic>P<\/jats:italic>=not significant) and central BP (\u221215.7\/\u22127.6\u2003mm\u2003Hg for valsartan and \u221219.2\/\u221210.3\u2003mm\u2003Hg for amlodipine, <jats:italic>P&lt;<\/jats:italic>.05 for central DBP). Both treatments similarly reduced the carotid\u2010femoral PWV (\u22121.9 vs \u22121.7\u2003m\/s; <jats:italic>P<\/jats:italic>=not significant). Amlodipine was associated with a higher incidence of peripheral edema compared with the valsartan group (77% vs 14%, <jats:italic>P&lt;<\/jats:italic>.001). BP lowering in postmenopausal women led to a reduction in arterial stiffness as assessed by PWV measurement. Both regimens reduced PWV to a similar degree after 38\u2003weeks of treatment despite differences in central BP lowering, suggesting that the effect of valsartan on PWV is mediated through nonhemodynamic effects.<\/jats:p>","DOI":"10.1111\/jch.12004","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T13:17:15Z","timestamp":1347455835000},"page":"773-778","source":"Crossref","is-referenced-by-count":28,"title":["Changes in Aortic Pulse Wave Velocity in Hypertensive Postmenopausal Women: Comparison Between a Calcium Channel Blocker vs Angiotensin Receptor Blocker Regimen"],"prefix":"10.1111","volume":"14","author":[{"given":"Daniel","family":"Hayoz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dion H.","family":"Zappe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie 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