{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:24:47Z","timestamp":1788279887580,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T00:00:00Z","timestamp":1355097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>The Ambulatory Blood Pressure Control and Home Blood Pressure (Morning and Evening) Lowering By N\u2010Channel Blocker Cilnidipine (ACHIEVE\u2010ONE) trial is a large\u2010scale clinical study on blood pressure (BP) and pulse rate (PR) in the real world with use of cilnidipine, a unique L\/N\u2010type Ca channel blocker, possessing a suppressive action on increased sympathetic activity in patients with essential hypertension. The effects of cilnidipine on morning hypertension were examined. The authors examined 2319 patients treated with cilnidipine for 12\u2003weeks. Clinic systolic BP (SBP) decreased by 19.6\u2003mm Hg from 155.0\u2003mm Hg, whereas morning SBP decreased by 17.0\u2003mm Hg from 152.9\u2003mm Hg after 12\u2010week cilnidipine treatment. Cilnidipine reduced both morning SBP and PR more markedly in patients with higher baseline morning SBP (\u22123.2\u2003mm Hg and \u22121.3\u2003beats per minute in the first quartile of morning SBP, \u221230.9\u2003mm Hg and \u22123.2\u2003beats per minute in the fourth quartile), and also reduced both morning PR and SBP more markedly in patients with higher baseline morning PR (0.6\u2003beats per minute and \u221215.6\u2003mm Hg in &lt;70\u2003beats per minute, and \u22129.7\u2003beats per minute and \u221220.2\u2003mm Hg in \u226585\u2003beats per minute). Cilnidipine significantly reduced BP and PR in hypertensive patients at the clinic and at home, especially with higher BP and PR in the morning. <jats:italic>J Clin Hypertens (Greenwich).<\/jats:italic> 2012; 00:00\u201300. \u00a92012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1111\/jch.12042","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T12:10:12Z","timestamp":1355400612000},"page":"133-142","source":"Crossref","is-referenced-by-count":29,"title":["The Effects of the L\u200a\/\u200aN\u2010Type Calcium Channel Blocker (Cilnidipine) on Sympathetic Hyperactive Morning Hypertension: Results From 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