{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:16:33Z","timestamp":1791494193069,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T00:00:00Z","timestamp":1355443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Aldosterone inhibition with mineralcorticoid receptor antagonists (MRAs) is an effective treatment for resistant hypertension. Aldosterone synthase inhibitors (ASIs) are currently being investigated as a new therapeutic strategy to reduce aldosterone secretion from the adrenal gland. In this study, the efficacy and safety of the first\u2010generation ASI LCI699 (0.25\u2003mg twice daily, 1\u2003mg 4 once daily, and 0.5\u2003mg\/1\u2003mg twice daily) was compared with placebo and eplerenone (50\u2003mg twice daily), in patients with resistant hypertension. Placebo\u2010adjusted decreases in systolic blood pressure (BP) with LCI699 ranged from 2.6\u2003mm\u2003Hg to 4.3\u2003mm\u2003Hg at week 8; changes in diastolic BP ranged from +0.3\u2003mm\u2003Hg to \u22121.2\u2003mm\u2003Hg. However, reductions were smaller than observed with eplerenone 50\u2003mg twice daily (9.9\u2003mm\u2003Hg and 2.9\u2003mm\u2003Hg for systolic and diastolic BP, respectively) and not statistically significant vs placebo. LCI699 suppressed plasma aldosterone levels in a dose\u2010related manner with corresponding dose\u2010dependent increases in plasma renin activity and plasma 11\u2010deoxycorticosterone. LCI699 and eplerenone were well tolerated. These data demonstrate that aldosterone synthesis inhibition with LCI699 lowers BP modestly in patients with resistant hypertension. Aldosterone synthesis inhibition might offer an attractive adjunct to aldosterone receptor blockade, although the potential of a combination MRA\/ASI has not yet been tested. <jats:italic>J Clin Hypertens (Greenwich)<\/jats:italic>. 2012;00:00\u201300. \u00a92012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1111\/jch.12051","type":"journal-article","created":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T15:37:42Z","timestamp":1355499462000},"page":"186-192","source":"Crossref","is-referenced-by-count":98,"title":["Study of Aldosterone Synthase Inhibition as an Add\u2010On Therapy in Resistant Hypertension"],"prefix":"10.1111","volume":"15","author":[{"given":"Adam D.","family":"Karns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline 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