{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:37:55Z","timestamp":1782909475960,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T00:00:00Z","timestamp":1365638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>\u201cSuccessful\u201d adrenal vein catheterization in <jats:styled-content style=\"fixed-case\">p<\/jats:styled-content>rimary <jats:styled-content style=\"fixed-case\">a<\/jats:styled-content>ldosteronism (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>) is often defined by a ratio of &gt;3:1 of cortisol in the adrenal vein vs the <jats:styled-content style=\"fixed-case\">inferior vena cava<\/jats:styled-content>. Non\u2010use of corticotropin (<jats:styled-content style=\"fixed-case\">ACTH)<\/jats:styled-content> during sampling may increase the apparent failure rate of adrenal vein catheterization due to lower cortisol levels. A retrospective study was performed on all patients with confirmed unilateral <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>une 2005 and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ugust 2011. Adrenal vein sampling (<jats:styled-content style=\"fixed-case\">AVS)<\/jats:styled-content> included simultaneous bilateral baseline samples with repeat sampling 15\u00a0minutes after intravenous infusion of 250\u00a0\u03bcg of <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ortrosyn (<jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>). Successful catheter placement was judged as adrenal cortisol:<jats:styled-content style=\"fixed-case\">IVC<\/jats:styled-content> cortisol of &gt;3:1, applied to both <jats:styled-content style=\"fixed-case\">baseline<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content> samples and lateralization of aldosteronism was judged as normalized aldosterone\/cortisol (<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>) ratio &gt;3 times the contralateral <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> ratio. In <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content> samples, 94% of right\u2010sided catheterizations were biochemically successful with 100% success on the left. Among <jats:styled-content style=\"fixed-case\">baseline<\/jats:styled-content> samples, only 47% of right\u2010 and 44% of left\u2010sided samples met the 3:1 cortisol criteria. However, 95% of apparent \u201cfailed\u201d <jats:styled-content style=\"fixed-case\">baseline<\/jats:styled-content> cortisol sets still showed lateralization of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> ratios that matched the ultimate pathology. Non\u2013<jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\u2010stimulated samples may be incorrectly judged as failed catheter placement when a 3:1 ratio is used. <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\u2010stimulated sampling is the preferred means to confirm catheterization during <jats:styled-content style=\"fixed-case\">AVS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jch.12096","type":"journal-article","created":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T14:55:19Z","timestamp":1365692119000},"page":"480-484","source":"Crossref","is-referenced-by-count":41,"title":["Catheterization During Adrenal Vein Sampling for Primary Aldosteronism: Failure to Use (1\u201324) <scp>ACTH<\/scp> May Increase Apparent Failure Rate"],"prefix":"10.1111","volume":"15","author":[{"given":"Gregory A.","family":"Kline","sequence":"first","affiliation":[{"name":"Division of Endocrinology Department of Medicine University of Calgary Calgary 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