{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:24:58Z","timestamp":1788279898586,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T00:00:00Z","timestamp":1367193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ajinomoto Pharmaceuticals Co., LTD"},{"name":"Mochida Pharmaceutical Co., LTD"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>The authors examined the effect of cilnidipine, a unique <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\u2010type calcium channel blocker, on abnormal nocturnal blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) dipping in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese hypertensive patients in the real world. The Ambulatory Blood Pressure Control and Home Blood Pressure (Morning and Evening) Lowering by <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\u2010Channel Blocker Cilnidipine (<jats:styled-content style=\"fixed-case\">ACHIEVE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ONE)<\/jats:styled-content>, a large\u2010scale clinical study, was designed to evaluate the effects of cilnidipine in daily medical practice. Among the study, 24\u2010hour ambulatory <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> data were obtained from 615 patients and classified according to their nocturnal dipping status as extreme dippers, dippers, nondippers, or risers. A 12\u2010week treatment with cilnidipine significantly reduced 24\u2010hour <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> in all groups (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>&lt;.001). Changes in nocturnal systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>) from baseline were \u221217.9\u00a0mm Hg from 154.6\u00a0mm Hg in risers and \u221211.9\u00a0mm Hg from 142.1\u00a0mm Hg, \u22126.6\u00a0mm Hg from 128.5\u00a0mm Hg, and 0.1\u00a0mm Hg from 115.8\u00a0mm Hg in nondippers, dippers, and extreme dippers, respectively. Changes from baseline in nocturnal <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> reduction rate were 8.2% in risers (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>&lt;.001) but \u22127.0% in extreme dippers (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>&lt;.001), while no change was observed in the nighttime <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> reduction rate for the total patients (\u22120.2%\u00b19.6%, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>=.617). Cilnidipine partially, but significantly, restored abnormal nocturnal dipping status toward a normal dipping pattern in hypertensive patients.<\/jats:p>","DOI":"10.1111\/jch.12113","type":"journal-article","created":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T13:10:56Z","timestamp":1367241056000},"page":"465-472","source":"Crossref","is-referenced-by-count":24,"title":["Effect of a Novel Calcium Channel Blocker on Abnormal Nocturnal Blood Pressure in Hypertensive Patients"],"prefix":"10.1111","volume":"15","author":[{"given":"Kazuomi","family":"Kario","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine Jichi Medical University School of Medicine Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Nariyama","sequence":"additional","affiliation":[{"name":"Osaka General Hospital of West Japan Railway Company Osaka 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