{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:32:23Z","timestamp":1765827143251,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T00:00:00Z","timestamp":1370822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>The authors conducted a randomized, controlled, multicenter trial, in which they assigned well\u2010controlled hypertensive participants aged 55\u00a0years and older with moderate hypercholesterolemia to receive pravastatin (n=5170) or usual care (n=5185) for 4 to 8\u00a0years, when trial therapy was discontinued. Passive surveillance using national databases to ascertain deaths and hospitalizations continued for a total follow\u2010up of 8 to 13\u00a0years to assess whether mortality and morbidity differences persisted or new differences developed. During the post\u2010trial period, fatal and nonfatal outcomes were available for 98% and 64% of participants, respectively. The primary outcome was all\u2010cause mortality and the secondary outcomes included cardiovascular mortality, coronary heart disease (<jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>), stroke, heart failure, cardiovascular disease, and end\u2010stage renal disease. No significant differences appeared in mortality for pravastatin vs usual care (hazard ratio [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>], 0.96; 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>], 0.89\u20131.03) or other secondary outcomes. Similar to the previously reported in\u2010trial result, there was a significant treatment effect for <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content> in black patients (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 0.79; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.64\u20130.98). However, the in\u2010trial result showing a significant treatment by race effect did not remain significant during the entire follow\u2010up (<jats:italic>P<\/jats:italic>=.08). These findings are consistent with evidence from other large trials that show statins prevent <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content> and add evidence that they are effective for <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content> prevention in black patients.<\/jats:p>","DOI":"10.1111\/jch.12139","type":"journal-article","created":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T13:34:26Z","timestamp":1370871266000},"page":"542-554","source":"Crossref","is-referenced-by-count":24,"title":["Long\u2010Term Follow\u2010Up of Moderately Hypercholesterolemic Hypertensive Patients Following Randomization to Pravastatin vs Usual Care: The Antihypertensive and Lipid\u2010Lowering Treatment to Prevent Heart Attack Trial (<scp>ALLHAT<\/scp>\u2010<scp>LLT<\/scp>)"],"prefix":"10.1111","volume":"15","author":[{"given":"Karen L.","family":"Margolis","sequence":"first","affiliation":[{"name":"Health Partners Institute for Education and Research Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry R.","family":"Davis","sequence":"additional","affiliation":[{"name":"The University of Texas School of Public Health Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Baimbridge","sequence":"additional","affiliation":[{"name":"The University of Texas School of Public Health Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry O.","family":"Ciocon","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Florida Weston FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aloysius B.","family":"Cuyjet","sequence":"additional","affiliation":[{"name":"The Nassau University Medical Center East Meadow NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Dart","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Foundation Marshfield WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula T.","family":"Einhorn","sequence":"additional","affiliation":[{"name":"The National Heart, Lung, and Blood Institute Bethesda MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles E.","family":"Ford","sequence":"additional","affiliation":[{"name":"The University of Texas School of Public Health Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gordon","sequence":"additional","affiliation":[{"name":"The National Heart, Lung, and Blood Institute Bethesda MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J","family":"Hartney","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center Augusta Augusta GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Julian Haywood","sequence":"additional","affiliation":[{"name":"LAC &amp; USC Medical Center Keck School of Medicine Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Holtzman","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center Minneapolis Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Mathis","sequence":"additional","affiliation":[{"name":"Mercer University Macon GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Oparil","sequence":"additional","affiliation":[{"name":"The University of Alabama at Birmingham Birmingham AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey L.","family":"Probstfield","sequence":"additional","affiliation":[{"name":"The University of Washington Medical Center Seattle WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara M.","family":"Simpson","sequence":"additional","affiliation":[{"name":"The University of Texas School of Public Health Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Stokes","sequence":"additional","affiliation":[{"name":"Christie Clinic Champaign IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas B.","family":"Wiegmann","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center Kansas City Kansas City MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff D.","family":"Williamson","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine Winston\u2010Salem NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"ALLHAT Collaborative Research Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(96)00037-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.2998"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.11.015"},{"key":"e_1_2_10_5_1","unstructured":"Extension protocol: Antihypertensive and Lipid\u2010Lowering Treatment to Prevent Heart Attack Trial.https:\/\/allhat.sph.uth.tmc.edu\/Forms\/ExtensionProtocol.pdf. 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