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Research has suggested that antihypertensive medication classes may differentially impact <jats:styled-content style=\"fixed-case\">VVV<\/jats:styled-content>. This study evaluated whether antihypertensive medication class differentially impacted <jats:styled-content style=\"fixed-case\">BP VVV<\/jats:styled-content> among hypertensive individuals in a clinical, \u201creal\u2010world\u201d setting as well as the association between <jats:styled-content style=\"fixed-case\">VVV<\/jats:styled-content> and patient characteristics. Clinical observational data were extracted for adults (mean age, 63; 56% female, 86% <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>aucasian) with hypertension from the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ercy <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>pic<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>are <jats:styled-content style=\"fixed-case\">EHR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>erived <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>atabase (<jats:styled-content style=\"fixed-case\">MEDD<\/jats:styled-content>) (n=183,374) who had at least 4 outpatient visits with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> readings. A multilevel mixed model for change over time estimated between\u2010 and within\u2010subject effects on the absolute real <jats:styled-content style=\"fixed-case\">VVV<\/jats:styled-content> of systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>. Diuretics significantly lowered <jats:styled-content style=\"fixed-case\">VVV <\/jats:styled-content>(\u03b2=\u22120.32[\u22120.39 to\u22120.25]) and \u03b1\u2010\/\u03b2\u2010blockers resulted in the highest <jats:styled-content style=\"fixed-case\">VVV <\/jats:styled-content>(\u03b2=0.89 [0.77\u20131.00]). Being older, female, and having a higher systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and certain comorbid conditions significantly raised <jats:styled-content style=\"fixed-case\">VVV<\/jats:styled-content> (<jats:italic>P<\/jats:italic>&lt;.001). The findings from the <jats:styled-content style=\"fixed-case\">MEDD<\/jats:styled-content> were consistent in general with other research on <jats:styled-content style=\"fixed-case\">BP VVV<\/jats:styled-content>. However, the magnitude of effect of antihypertensive medication class and patient characteristics was relatively low (&lt;10% of the <jats:styled-content style=\"fixed-case\">BP VVV<\/jats:styled-content> variance for any one variable). More research is needed to evaluate the extent to which the class of antihypertensive medication class impacts <jats:styled-content style=\"fixed-case\">BP VVV<\/jats:styled-content> in the outpatient setting.<\/jats:p>","DOI":"10.1111\/jch.12165","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T12:52:41Z","timestamp":1373633561000},"page":"655-662","source":"Crossref","is-referenced-by-count":26,"title":["Medication Class Effects on Visit\u2010to\u2010Visit Variability of Blood Pressure Measurements: Analysis of Electronic Health Record Data in the \u201cReal World\u201d"],"prefix":"10.1111","volume":"15","author":[{"given":"Timothy R.","family":"Smith","sequence":"first","affiliation":[{"name":"Center for Innovative Care Mercy Health Chesterfield MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Joseph P.","family":"Drozda","sequence":"additional","affiliation":[{"name":"Center for Innovative Care Mercy Health Chesterfield MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Vanslette","sequence":"additional","affiliation":[{"name":"Center for Innovative Care Mercy Health Chesterfield MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda S.","family":"Hoeffken","sequence":"additional","affiliation":[{"name":"Center for Innovative Care Mercy Health Chesterfield MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Center for Innovative Care Mercy Health Chesterfield MO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60655-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11911-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000105052.65787.35"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60309-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000229551"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60308-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.162255"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(00)00228-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2007.25"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7445.933"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90878-9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000229551"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70066-1"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834cf213"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60235-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67185-1"},{"key":"e_1_2_8_18_1","unstructured":"Physician Quality Reporting System.2011.http:\/\/www.cms.gov\/Medicare\/Quality-Initiatives-Patient-Assessment-Instruments\/PQRS\/index.html?redirect=\/pqri\/. 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