{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:17:08Z","timestamp":1696331828541},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,9,16]],"date-time":"2013-09-16T00:00:00Z","timestamp":1379289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>A direct switch of candesartan to the fixed\u2010dose combination olmesartan\/amlodipine in uncontrolled hypertension is a frequent clinical requirement but is not covered by current labeling. An open\u2010label, prospective, single\u2010arm phase IIIb study was performed in patients with 32\u00a0mg candesartan followed by olmesartan\/amlodipine 40\/10\u00a0mg. The primary endpoint was change in mean daytime systolic blood pressure (BP). Mean daytime systolic BP was reduced by 9.2\u00b112.6\u00a0mm\u00a0Hg (<jats:italic>P<\/jats:italic>&lt;.0001) after substituting candesartan for olmesartan\/amlodipine (baseline BP 140.2\u00b19.7\u00a0mm\u00a0Hg). The reduction in office BP was 9.4\u00b118.4\/4.0\u00b19.6\u00a0mm\u00a0Hg; <jats:italic>P<\/jats:italic>&lt;.002). Overall, 61.3% of patients achieved a target BP &lt;140\/90\u00a0mm\u00a0Hg using office BP and &lt;135\/85\u00a0mm\u00a0Hg using ambulatory BP measurement. There were 8 adverse events with a possible relation to study drug and 1 unrelated serious adverse events. In conclusion, patients with uncontrolled moderate arterial hypertension being treated using candesartan monotherapy achieve a further reduction of BP when switched directly to a fixed\u2010dose combination of olmesartan 40\u00a0mg\/amlodipine 10\u00a0mg.<\/jats:p>","DOI":"10.1111\/jch.12202","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T13:12:35Z","timestamp":1381237955000},"page":"815-819","source":"Crossref","is-referenced-by-count":2,"title":["Daytime Systolic Ambulatory Blood Pressure With a Direct Switch Between Candesartan Monotherapy and the Fixed\u2010Dose Combination Olmesartan\/Amlodipine in Patients With Uncontrolled Essential Hypertension (<scp>SEVICONTROL<\/scp>\u20101)"],"prefix":"10.1111","volume":"15","author":[{"given":"Claudia","family":"Zemmrich","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Pharmakologie und pr\u00e4ventive Medizin Mahlow and Cloppenburg 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