{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:37:04Z","timestamp":1790523424919,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T00:00:00Z","timestamp":1383177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Diabetes and Obesity Discovery Institute of GRU"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["L077230"],"award-info":[{"award-number":["L077230"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Overactivity of the epithelial sodium channel (<jats:styled-content style=\"fixed-case\">EN<\/jats:styled-content>a<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>) is considered to be one mechanism underlying obesity\u2010related blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) elevation. In an open\u2010labeled, nonplacebo\u2010controlled clinical trial (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>linicaltrials.gov: <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\u201001308983), the authors aimed to comprehensively evaluate the effects of amiloride monotherapy, an <jats:styled-content style=\"fixed-case\">EN<\/jats:styled-content>a<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> blocker, on <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and cardiovascular risk in young adults with prehypertension (n=17). The mean body mass index of participants was 28.45\u00b11.30\u00a0kg\/m<jats:sup>2<\/jats:sup>. Following 10\u00a0mg daily amiloride for 4\u00a0weeks, peripheral systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>), central <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>, and carotid\u2010radial pulse wave velocity were significantly reduced by \u22127.06\u00b12.25\u00a0mm Hg, \u22127.68\u00b12.56\u00a0mm Hg, and \u22120.72\u00b10.33\u00a0m\/s, respectively, whereas flow\u2010mediated dilation was significantly increased by 2.2\u00b10.9%. Following amiloride monotherapy for 4\u00a0weeks, a significant increase in serum aldosterone was observed (5.85\u00b12.45\u00a0ng\/dL). ENaC inhibition by amiloride may be used as an early intervention to halt the progression to full hypertension and cardiovascular disease in young adults with prehypertension.<\/jats:p>","DOI":"10.1111\/jch.12218","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T10:58:08Z","timestamp":1383217088000},"page":"47-53","source":"Crossref","is-referenced-by-count":15,"title":["Epithelial Sodium Channel Inhibition by Amiloride on Blood Pressure and Cardiovascular Disease Risk in Young Prehypertensives"],"prefix":"10.1111","volume":"16","author":[{"given":"Jigar","family":"Bhagatwala","sequence":"first","affiliation":[{"name":"Georgia Prevention Center Medical College of Georgia Georgia Regents University Augusta GA"},{"name":"Department of Internal Medicine Medical College of Georgia Georgia Regents University Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan A.","family":"Harris","sequence":"additional","affiliation":[{"name":"Georgia Prevention Center Medical College of Georgia Georgia Regents University Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samip J.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Georgia Prevention Center Medical College of Georgia Georgia Regents University Augusta GA"},{"name":"Department of Internal Medicine Medical College of Georgia Georgia Regents University Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Georgia Prevention Center Medical College of Georgia Georgia Regents University Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Georgia Prevention Center Medical College of Georgia Georgia Regents University Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishita","family":"Kotak","sequence":"additional","affiliation":[{"name":"Georgia Prevention Center Medical College of Georgia Georgia Regents University Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichole","family":"Seigler","sequence":"additional","affiliation":[{"name":"Georgia Prevention Center Medical College of Georgia Georgia Regents University Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary L.","family":"Pierce","sequence":"additional","affiliation":[{"name":"Georgia Prevention Center Medical College of Georgia Georgia Regents University Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent M.","family":"Egan","sequence":"additional","affiliation":[{"name":"General Medicine Division Department of Medicine Medical University of South Carolina Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbin","family":"Dong","sequence":"additional","affiliation":[{"name":"Georgia Prevention Center Medical College of Georgia Georgia Regents University Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.91"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060838"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1001\/archinte.1997.00440270105009","article-title":"Effects of weight loss and sodium reduction intervention on blood pressure and hypertension incidence in overweight people with high\u2010normal blood pressure. 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