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Additionally, several mechanisms have been proposed that might confer cocoa's possible health benefit, but no consensus has been reached on cocoa's physiologic role in promoting cardiovascular health. Flavanols, as well as theobromine, may contribute to enhancements in endothelial function and subsequent improvements in various contributors to cardiovascular disease (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>) including hypertension, platelet aggregation and adhesion, insulin resistance, and hypercholesterolemia. While the benefits of cocoa may be altered at the various stages of growth, development, and production, it appears that for many people \u201chealthy\u201d dark chocolate may, indeed, provide a pleasurable role in <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> risk reduction. The objectives of this review are to discuss the associations of cocoa with decreased blood pressure and improved <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> risk, to describe the possible mechanisms for these potential benefits, and to highlight considerations for the use of cocoa as a dietary supplement.<\/jats:p>","DOI":"10.1111\/jch.12223","type":"journal-article","created":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T10:02:41Z","timestamp":1386928961000},"page":"101-106","source":"Crossref","is-referenced-by-count":27,"title":["Chocolate\u2014Guilty Pleasure or Healthy Supplement?"],"prefix":"10.1111","volume":"16","author":[{"given":"Laura S.","family":"Latham","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of Mississippi Medical Center Jackson MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeb K.","family":"Hensen","sequence":"additional","affiliation":[{"name":"Department of Medicine University 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